PTX3 predicts severe disease in febrile patients at the emergency department

Martijn D. De Kruif, Maarten Limper, Karlien Sierhuis, Jiri F P Wagenaar, C. Arnold Spek, Cecilia Garlanda, Alessia Cotena, Alberto Mantovani, Hugo ten Cate, Pieter H. Reitsma, Eric C M van Gorp

Research output: Contribution to journalArticlepeer-review


Objectives: The long pentraxin PTX3 is a promising marker of disease severity in severely ill patients. In order to identify patients warranting critical care as quickly as possible, we investigated the value of PTX3 as a biomarker for disease severity in patients presenting with fever at the emergency department. Methods: Levels of PTX3 were measured in 211 febrile patients at the emergency and the levels were linked to markers of disease severity including admittance to a special care unit, bloodstream infection and congestive heart failure. Results: In comparison to median baseline levels of 2.30. ng/ml (interquartile range 1.66-3.67. ng/ml), levels of PTX3 were significantly elevated in patients admitted to the intensive-/medium care unit (median value 44.4. ng/ml, interquartile range 13.6-105.9. ng/ml) and in patients referred to the ward (median value 14.2. ng/ml, interquartile range 7.01-25.1. ng/ml). In addition, PTX3 was associated with duration of hospital stay and acute congestive heart failure. The levels were predictive for bloodstream infection (AUC=0.71; 95% CI 0.62-0.81). Conclusions: PTX3 may be a useful marker for differentiation of patients with severe disease in patients presenting with fever to the emergency department.

Original languageEnglish
Pages (from-to)122-127
Number of pages6
JournalJournal of Infection
Issue number2
Publication statusPublished - Feb 2010


  • Biological marker
  • Emergency department
  • Fever
  • Infection
  • Inflammation
  • Pentraxin

ASJC Scopus subject areas

  • Microbiology (medical)
  • Infectious Diseases


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