Puerperal lactation, gonadotropin release and estradiol release: Effects of metergoline and bromocriptine

A. E. Pontiroli, R. Di Micco, A. Sartani, A. De Pasqua, E. Zanardi

Research output: Contribution to journalArticlepeer-review

Abstract

The exact cause of amenorrhea during the Puerperium is still a matter of debate. PRL might inhibit primarily the release of FSH and LH or their stimulating effects on the ovary. In the study presented here, 28 healthy women were investigated, 13 of them lactating puerperae. In the other 15, lactation was prevented by drugs (metergoline in 9, bromocriptine in 6). The women’s serum PRL, FSH, LH, ß-HCG and 17ß-estradiol as well as their FSH and LH response to LHRH (100 μg i.v.) were tested 1, 3, 7 and 14 days after vaginal delivery. Scrum PRL levels remained elevated in the lactating puerperae and dropped in the puerperae treated with metergoline or bromocriptine. The pattern of FSH, LH and ß-HCG levels as well as the FSH and LH response to LHRH were superimposable in lactating and in nonlactating women. 17ß-estradiol levels dropped in all puerperae from day 1 to 7, but rose from day 7 to 14 only in the puerperae treated with metergoline or bromocriptine and not in the lactating women. These data indicate that PRL directly affects the ovarian response to FSH and LH, whereas the release of FSH and LH remains unaffected. A stimulatory effect of metergoline and bromocriptine on the ovarian steroidogenesis cannot be excluded.

Original languageEnglish
Pages (from-to)179-184
Number of pages6
JournalGynecologic and Obstetric Investigation
Volume24
Issue number3
DOIs
Publication statusPublished - 1987

Keywords

  • Bromocriptine
  • Estradiol
  • Gonadotropins
  • Infertility
  • Metergoline
  • Prolactin
  • Puerperal lactation

ASJC Scopus subject areas

  • Obstetrics and Gynaecology
  • Reproductive Medicine

Fingerprint Dive into the research topics of 'Puerperal lactation, gonadotropin release and estradiol release: Effects of metergoline and bromocriptine'. Together they form a unique fingerprint.

Cite this