Pulmonary and Systemic Pharmacokinetics of Colistin Following a Single Dose of Nebulized Colistimethate in Mechanically Ventilated Neonates

Narongsak Nakwan, Pichaya Lertpichaluk, Kulkanya Chokephaibulkit, Paola Villani, Mario Regazzi, Roberto Imberti

Research output: Contribution to journalArticle

Abstract

The purpose of this study was to evaluate the pulmonary and systemic pharmacokinetics of colistin following a single dose of nebulized colistimethate sodium (CMS) in mechanically ventilated neonates. We administered a single dose of nebulized CMS (approximately 120,000 IU/kg of CMS, equivalent to 4 mg/kg colistin base activity) to 6 ventilated neonates with ventilator-associated pneumonia. The median gestational age was 39 weeks (range, 32-39 weeks). Mean (±SD) tracheal aspirate colistin maximum concentration (Cmax), area under the concentration-time curve (AUC0-24) and t1/2 were 24.0 ± 8.2 μg/mL, 147.6 ± 53.5 μg·hours/mL and 9.8 ± 5.5 hours, respectively. The plasma concentrations of colistin were low. In neonates, a single nebulized dose of CMS (120,000 IU) resulted in high local concentrations for at least 12 hours and low systemic concentrations of colistin. Twice daily nebulization might be more appropriate.

Original languageEnglish
Pages (from-to)961-963
Number of pages3
JournalPediatric Infectious Disease Journal
Volume34
Issue number9
DOIs
Publication statusPublished - Sep 26 2015

Keywords

  • colistin
  • inhalation
  • neonates
  • pharmacokinetics
  • ventilator-associated pneumonia

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Infectious Diseases
  • Microbiology (medical)

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