Ipertensione arteriosa polmonare nei pazienti adulti con cardiopatia congenita.

Translated title of the contribution: [Pulmonary arterial hypertension in adult patients with congenital heart disease].

G. Serino, F. Giacomazzi

Research output: Contribution to journalArticle

Abstract

Pulmonary Hypertension (PH) is definited by a mean pulmonary artery pressure (PAPm) >25 mmHg at rest. The Dana Point 2008 Revised Classification System represents the most recent classification system update with respect of various etiologies of PH. About 10 % of adolescents or adults with uncorrected congenital heart disease (CHD) with left-to-right shunt and high pulmonary blood flow develop Pulmonary Arterial Hypertension (PAH) . Progressive vascular remodeling and increase in pulmonary vascular resistance (PVR) may ultimately lead to reversal of the shunt (pulmonary to systemic) causing cyanosis and determining the so-called Eisenmenger Syndrome (ES). Recent advances in the early diagnosis and medical targeted treatment of adult patients with CHD-PAH and ES can improve PAP, PVR and exercise tolerance, together with NYHA Class and survival, and may potentially reverse the vascular remodeling process in selected patients.

Translated title of the contribution[Pulmonary arterial hypertension in adult patients with congenital heart disease].
Original languageItalian
Pages (from-to)274-279
Number of pages6
JournalPediatria Medica e Chirurgica
Volume32
Issue number6
Publication statusPublished - Nov 2010

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Surgery

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