TY - JOUR
T1 - Pulmonary blastomas of childhood
T2 - Histologic, immunohistochemical, ultrastructural aspects and therapeutic considerations
AU - Boldrini, Renata
AU - Devito, Rita
AU - Diomedi-Camassei, Francesca
AU - Francalanci, Paola
AU - Inserra, Alessandro
AU - Boglino, Camillo
AU - Donfrancesco, Alberto
AU - Jenkner, Alessandro
AU - Callea, Francesco
PY - 2005/11
Y1 - 2005/11
N2 - Pulmonary blastomas are rare neoplasms typically occurring in patients of pediatric age, clinically characterized by fever, respiratory distress, and radiologic findings of a pulmonary cystic and/or solid mass with partial or complete obliteration of emithorax. Their behavior is aggressive and outcome is poor due to frequent relapses and metastases. The histological, immunohistochemical, and ultrastructural aspects of a personal series of 6 cases of pulmonary blastoma are described and the differences between childhood and adult types are stressed. Due to the aggressiveness of these rare tumors, therapeutic management is quite difficult. The expression of the transmembrane tyrosin kinase receptor c-kit in all the solid cases of this series leads the authors to hypothize new possible therapeutic implications for these tumors.
AB - Pulmonary blastomas are rare neoplasms typically occurring in patients of pediatric age, clinically characterized by fever, respiratory distress, and radiologic findings of a pulmonary cystic and/or solid mass with partial or complete obliteration of emithorax. Their behavior is aggressive and outcome is poor due to frequent relapses and metastases. The histological, immunohistochemical, and ultrastructural aspects of a personal series of 6 cases of pulmonary blastoma are described and the differences between childhood and adult types are stressed. Due to the aggressiveness of these rare tumors, therapeutic management is quite difficult. The expression of the transmembrane tyrosin kinase receptor c-kit in all the solid cases of this series leads the authors to hypothize new possible therapeutic implications for these tumors.
KW - Pleuropulmonary blastoma
KW - Therapeutic management
KW - Transmembrane tyrosin kinase receptor c-kit
KW - Ultrastructural pattern
UR - http://www.scopus.com/inward/record.url?scp=28844475136&partnerID=8YFLogxK
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U2 - 10.1080/01913120500323456
DO - 10.1080/01913120500323456
M3 - Article
C2 - 16316950
AN - SCOPUS:28844475136
VL - 29
SP - 493
EP - 501
JO - Ultrastructural Pathology
JF - Ultrastructural Pathology
SN - 0191-3123
IS - 6
ER -