Pulmonary blastomas of childhood: Histologic, immunohistochemical, ultrastructural aspects and therapeutic considerations

Renata Boldrini, Rita Devito, Francesca Diomedi-Camassei, Paola Francalanci, Alessandro Inserra, Camillo Boglino, Alberto Donfrancesco, Alessandro Jenkner, Francesco Callea

Research output: Contribution to journalArticlepeer-review

Abstract

Pulmonary blastomas are rare neoplasms typically occurring in patients of pediatric age, clinically characterized by fever, respiratory distress, and radiologic findings of a pulmonary cystic and/or solid mass with partial or complete obliteration of emithorax. Their behavior is aggressive and outcome is poor due to frequent relapses and metastases. The histological, immunohistochemical, and ultrastructural aspects of a personal series of 6 cases of pulmonary blastoma are described and the differences between childhood and adult types are stressed. Due to the aggressiveness of these rare tumors, therapeutic management is quite difficult. The expression of the transmembrane tyrosin kinase receptor c-kit in all the solid cases of this series leads the authors to hypothize new possible therapeutic implications for these tumors.

Original languageEnglish
Pages (from-to)493-501
Number of pages9
JournalUltrastructural Pathology
Volume29
Issue number6
DOIs
Publication statusPublished - Nov 2005

Keywords

  • Pleuropulmonary blastoma
  • Therapeutic management
  • Transmembrane tyrosin kinase receptor c-kit
  • Ultrastructural pattern

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Instrumentation
  • Structural Biology

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