We describe a case of pulmonary carcinoma with myoepithelial differentiation, analogous to basal cell adenocarcinoma of salivary glands. The patient, a 60 year-old man, smoker, presented with three peripheral nodules of the left lung. Preoperative staging was negative for metastatic disease and the patient underwent a surgical resection of the nodules. After 22 months, the patient is alive with no evidence of disease. Microscopically, the tumours were composed of atypical cells arranged in lobules, separated by basal membrane-like material. Immunohistochemically, tomour cells were positive for cytokeratin AE1/AE3, cytokeratin 14, vimentin, calponin, S-100 protein and gliofibrillary acid protien (GFAP). Electron microscopy showed features of epithelial and myoid diferrentiation and confirmed the myoepithelial nature of the tumour. Pulmonary tumours with myoepithelial differentiation are rare, but they have a wide and distinctive morphological spectrum.
|Translated title of the contribution||Pulmonary carcinoma with myoepithelial differentiation, analogous to basal cell adenocarcinoma of salivary glands: A case report|
|Number of pages||6|
|Publication status||Published - Feb 2002|
ASJC Scopus subject areas
- Pathology and Forensic Medicine