Pulmonary embolism and 3-month outcomes in 4036 patients with venous thromboembolism and chronic obstructive pulmonary disease: Data from the RIETE registry

Laurent Bertoletti, Sara Quenet, Silvy Laporte, Joan C. Sahuquillo, Francisco Conget, José M. Pedrajas, Mar Martin, Ignacio Casado, Antonio Riera-Mestre, Manuel Monreal, Hervé Decousus, Paolo Prandoni, Benjamin Brenner, Raquel Barba, Pierpaolo Di Micco, Manolis Papadakis, Marijan Bosevski, Henri Bounameaux, Radovan Malỳ, J. I. ArcelusM. P. Arcos, A. Ballaz, R. Barba, M. Barrón, B. Barrón-Andrés, A. Blanco-Molina, J. Bosco, E. Chaves, I. Cañas, I. Casado, A. Contra, F. Conget, J. de Miguel, R. del Campo, J. del Toro, C. Falgá, C. Fernández-Capitán, F. Gabriel, P. Gallego, F. García-Bragado, O. Gavín, V. Gómez, J. González, V. Gracia, M. Guil, N. Guillem, J. Gutiérrez, L. Hernández, D. Hernández-Huerta, M. J. Jaras, D. Jiménez, S. Jiménez, M. Jiménez-Gil, J. L. Lobo, R. Lecumberri, L. López-Jiménez, A. Lorenzo, M. Macià, O. Madridano, P. J. Marchena, M. Martín, J. J. Martín-Villasclaras, M. Monreal, M. Morales, L. P. Morán, M. D. Nauffal, J. A. Nieto, M. J. Núñez, M. C. Mascareño, J. L. Ogea, R. Otero, J. M. Pedrajas, A. Riera-Mestre, M. A. Rodríguez-Dávila, P. Román, B. Román-Bernal, V. Roldán, V. Rosa, C. Royo, J. Ruíz, A. Ruiz-Gamietea, N. Ruiz-Giménez, J. C. Sahuquillo, R. Sánchez, J. F. Sánchez Muñoz-Torrero, S. Soler, M. J. Soto, G. Tiberio, C. Tolosa, J. Trujillo, F. Uresandi, M. Valdés, R. Valle, J. Vela, G. Vidal, J. Villalta, V. Zorrilla, L. Bertoletti, A. Bura-Riviere, P. Debourdeau, D. Farge-Bancel, M. Lamuraglia, I. Mahe, A. Merah, I. Quere, D. Babalis, M. Papadakis, B. Brenner, G. Barillari, M. Ciammaichella, P. Di Micco, F. Dalla Valle, R. Duce, M. La Regina, R. Maida, F. Orlandini, S. Pasca, C. Piovella, R. Poggio, P. Prandoni, R. Quintavalla, L. Rota, A. Schenone, D. Tonello, A. Visonà, B. Zalunardo, M. Bosevski, H. Bounameaux, R. Malý, J. Hirmerova, E. Salgado

Research output: Contribution to journalArticlepeer-review

Abstract

Background: Patients with chronic obstructive pulmonary disease (COPD) have a modified clinical presentation of venous thromboembolism (VTE) but also a worse prognosis than non-COPD patients with VTE. As it may induce therapeutic modifications, we evaluated the influence of the initial VTE presentation on the 3-month outcomes in COPD patients.Methods: COPD patients included in the on-going world-wide RIETE Registry were studied. The rate of pulmonary embolism (PE), major bleeding and death during the first 3 months in COPD patients were compared according to their initial clinical presentation (acute PE or deep vein thrombosis (DVT)).Results: Of the 4036 COPD patients included, 2452 (61%; 95% CI: 59.2-62.3) initially presented with PE. PE as the first VTE recurrence occurred in 116 patients, major bleeding in 101 patients and mortality in 443 patients (Fatal PE: first cause of death). Multivariate analysis confirmed that presenting with PE was associated with higher risk of VTE recurrence as PE (OR, 2.04; 95% CI: 1.11-3.72) and higher risk of fatal PE (OR, 7.77; 95% CI: 2.92-15.7).Conclusions: COPD patients presenting with PE have an increased risk for PE recurrences and fatal PE compared with those presenting with DVT alone. More efficient therapy is needed in this subtype of patients.

Original languageEnglish
Article number75
JournalRespiratory Research
Volume14
Issue number1
DOIs
Publication statusPublished - Jul 18 2013

Keywords

  • Chronic obstructive pulmonary diseases
  • Deep venous thrombosis
  • Prognosis
  • Pulmonary embolism
  • Venous thromboembolism

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine

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