Pulmonary embolism in pregnancy

E. Conti, L. Zezza, E. Ralli, C. Comito, L. Sada, J. Passerini, D. Caserta, S. Rubattu, C. Autore, M. Moscarini, M. Volpe

Research output: Contribution to journalArticle

Abstract

Venous thromboembolism (VTE) is a major cause of maternal morbidity and mortality during pregnancy or early after delivery, remaining a diagnostic and therapeutic challenge in both states. The absolute incidence of pregnancy-associated VTE has been reported as 1 in 1,000 to 1 in 2,000 deliveries. With 5-6 million new births computed in Europe in 2010, the potential clinical relevance of diagnosing and treating gravidic VTE is immediately evident. Fivefold higher in a pregnant as compared with a non-pregnant woman, VTE risk is also higher in postpartum than antepartum period. Ranked absolute and relative thrombotic risk may be described in the several thrombophilic conditions experienced by women at risk, according to which specific prophylactic and therapeutic recommendations have been formulated by recent guidelines. The main purpose of the present review article was to emphasize the most recent findings and recommendations in diagnostic strategies, discussing thrombophilic risk evaluation, as well as risks and benefits of various diagnostic techniques for both mother and fetus.

Original languageEnglish
Pages (from-to)251-270
Number of pages20
JournalJournal of Thrombosis and Thrombolysis
Volume37
Issue number3
DOIs
Publication statusPublished - 2014

Fingerprint

Venous Thromboembolism
Pulmonary Embolism
Pregnancy
Maternal Mortality
Postpartum Period
Fetus
Mothers
Parturition
Guidelines
Morbidity
Incidence
Therapeutics

Keywords

  • Anticoagulants
  • Computed tomography
  • Pregnancy
  • Prophylaxis
  • Risk factors
  • Venous thromboembolism

ASJC Scopus subject areas

  • Hematology
  • Cardiology and Cardiovascular Medicine
  • Medicine(all)

Cite this

Conti, E., Zezza, L., Ralli, E., Comito, C., Sada, L., Passerini, J., ... Volpe, M. (2014). Pulmonary embolism in pregnancy. Journal of Thrombosis and Thrombolysis, 37(3), 251-270. https://doi.org/10.1007/s11239-013-0941-9

Pulmonary embolism in pregnancy. / Conti, E.; Zezza, L.; Ralli, E.; Comito, C.; Sada, L.; Passerini, J.; Caserta, D.; Rubattu, S.; Autore, C.; Moscarini, M.; Volpe, M.

In: Journal of Thrombosis and Thrombolysis, Vol. 37, No. 3, 2014, p. 251-270.

Research output: Contribution to journalArticle

Conti, E, Zezza, L, Ralli, E, Comito, C, Sada, L, Passerini, J, Caserta, D, Rubattu, S, Autore, C, Moscarini, M & Volpe, M 2014, 'Pulmonary embolism in pregnancy', Journal of Thrombosis and Thrombolysis, vol. 37, no. 3, pp. 251-270. https://doi.org/10.1007/s11239-013-0941-9
Conti E, Zezza L, Ralli E, Comito C, Sada L, Passerini J et al. Pulmonary embolism in pregnancy. Journal of Thrombosis and Thrombolysis. 2014;37(3):251-270. https://doi.org/10.1007/s11239-013-0941-9
Conti, E. ; Zezza, L. ; Ralli, E. ; Comito, C. ; Sada, L. ; Passerini, J. ; Caserta, D. ; Rubattu, S. ; Autore, C. ; Moscarini, M. ; Volpe, M. / Pulmonary embolism in pregnancy. In: Journal of Thrombosis and Thrombolysis. 2014 ; Vol. 37, No. 3. pp. 251-270.
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