Pulmonary epithelial-myoepithelial tumor of unproven malignant potential: Report of a case and review of the literature

Giuseppe Pelosi, Filippo Fraggetta, Fausto Maffini, Piergiorgio Solli, Alessandra Cavallon, Giuseppe Viale

Research output: Contribution to journalArticle

Abstract

Epithelial-myoepithelial tumors of the lung are rare neoplasms whose biological behavior and clinical course still remain to be defined. A case of epithelial-myoepithelial tumor of the lung arising from bronchial mucosa-submucosa and occurring as a polypoid lesion of the upper left bronchus in a 47-year-old man is reported. The tumor did not infiltrate the cartilaginous wall of the bronchus and showed a biphasic histological appearance with a double layering of epithelial and myoepithelial cells. Myoepithelial spindle cells with eosinophilic cytoplasm were also observed. Mitotic figures were very rare and necrosis absent. Immunohistochemical study for epithelial and muscular markers confirmed the presence of a double-cell component in the tumor, namely epithelial and myoepithelial. The patient is alive and well, with no evidence of recurrent or metastatic disease 6 months after surgery. On the basis of the present case and the six previously reported cases, we suggest using the noncommittal term pulmonary epithelial-myoepithelial tumor of unproven malignant potential (PEMTUMP) for this type of neoplasm. In addition, we first introduce p63 as a novel marker for highlighting the myoepithelial cells of the respiratory tract and speculate on the role of these cells in the development of this unusual tumor.

Original languageEnglish
Pages (from-to)521-526
Number of pages6
JournalModern Pathology
Volume14
Issue number5
DOIs
Publication statusPublished - May 2001

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Keywords

  • Epithelial
  • Immunohistochemistry
  • Malignant potential
  • Myoepithelial
  • p27
  • p63
  • Tumor

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

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