TY - JOUR
T1 - Pulmonary fibrolysis in a patient with idiopathic pulmonary fibrosis
T2 - improvement of clinical and radiological pattern after treatment with pirfenidone
AU - Varone, Francesco
AU - Mastrobattista, Annelisa
AU - Franchi, Paola
AU - Viglietta, Luca
AU - Poletti, Venerino
AU - Tomassetti, Sara
AU - Dubini, Alessandra
AU - Tagliaboschi, Linda
AU - Calandriello, Lucio
AU - Farchione, Alessandra
AU - Larici, Anna Rita
PY - 2018/1/1
Y1 - 2018/1/1
N2 - Idiopathic Pulmonary Fibrosis (IPF) is a chronic, progressive, fibrosing interstitial pneumonia associated with the histologic and/or radiologic pattern of usual interstitial pneumonia (UIP). Nowadays, the high-resolution computed tomography pattern of “definite UIP” is enough to define a diagnosis of UIP without histological proof. This is pivotal especially in elderly patients with comorbidities. Early recognition of IPF is relevant for its prognostic implication. Some pharmacological strategies have been proposing novel molecules that tend to slow lung function decline, even though without healing fibrosis. We report a case of ex-heavy smoker male with IPF showing clinical and radiological improvement after 11 months of treatment with Pirfenidone. The definite diagnosis was challenging and it was reached by a multidisciplinary approach.
AB - Idiopathic Pulmonary Fibrosis (IPF) is a chronic, progressive, fibrosing interstitial pneumonia associated with the histologic and/or radiologic pattern of usual interstitial pneumonia (UIP). Nowadays, the high-resolution computed tomography pattern of “definite UIP” is enough to define a diagnosis of UIP without histological proof. This is pivotal especially in elderly patients with comorbidities. Early recognition of IPF is relevant for its prognostic implication. Some pharmacological strategies have been proposing novel molecules that tend to slow lung function decline, even though without healing fibrosis. We report a case of ex-heavy smoker male with IPF showing clinical and radiological improvement after 11 months of treatment with Pirfenidone. The definite diagnosis was challenging and it was reached by a multidisciplinary approach.
KW - high-resolution computed tomography
KW - honeycombing
KW - idiopathic pulmonary fibrosis
KW - multidisciplinary team
KW - pirfenidone
UR - http://www.scopus.com/inward/record.url?scp=84978269132&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84978269132&partnerID=8YFLogxK
U2 - 10.1111/crj.12515
DO - 10.1111/crj.12515
M3 - Article
C2 - 27322356
AN - SCOPUS:84978269132
VL - 12
SP - 347
EP - 351
JO - Clinical Respiratory Journal
JF - Clinical Respiratory Journal
SN - 1752-6981
IS - 1
ER -