Pulmonary fibrolysis in a patient with idiopathic pulmonary fibrosis: improvement of clinical and radiological pattern after treatment with pirfenidone

Francesco Varone, Annelisa Mastrobattista, Paola Franchi, Luca Viglietta, Venerino Poletti, Sara Tomassetti, Alessandra Dubini, Linda Tagliaboschi, Lucio Calandriello, Alessandra Farchione, Anna Rita Larici

Research output: Contribution to journalArticle

Abstract

Idiopathic Pulmonary Fibrosis (IPF) is a chronic, progressive, fibrosing interstitial pneumonia associated with the histologic and/or radiologic pattern of usual interstitial pneumonia (UIP). Nowadays, the high-resolution computed tomography pattern of “definite UIP” is enough to define a diagnosis of UIP without histological proof. This is pivotal especially in elderly patients with comorbidities. Early recognition of IPF is relevant for its prognostic implication. Some pharmacological strategies have been proposing novel molecules that tend to slow lung function decline, even though without healing fibrosis. We report a case of ex-heavy smoker male with IPF showing clinical and radiological improvement after 11 months of treatment with Pirfenidone. The definite diagnosis was challenging and it was reached by a multidisciplinary approach.

Original languageEnglish
Pages (from-to)347-351
Number of pages5
JournalClinical Respiratory Journal
Volume12
Issue number1
DOIs
Publication statusPublished - Jan 1 2018

Keywords

  • high-resolution computed tomography
  • honeycombing
  • idiopathic pulmonary fibrosis
  • multidisciplinary team
  • pirfenidone

ASJC Scopus subject areas

  • Immunology and Allergy
  • Pulmonary and Respiratory Medicine
  • Genetics(clinical)

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    Varone, F., Mastrobattista, A., Franchi, P., Viglietta, L., Poletti, V., Tomassetti, S., Dubini, A., Tagliaboschi, L., Calandriello, L., Farchione, A., & Larici, A. R. (2018). Pulmonary fibrolysis in a patient with idiopathic pulmonary fibrosis: improvement of clinical and radiological pattern after treatment with pirfenidone. Clinical Respiratory Journal, 12(1), 347-351. https://doi.org/10.1111/crj.12515