Pulmonary fibrosis following low-dose 1,3-bis (2-chloroethyl)-1-nitrosourea (BCNU) therapy

M. Melato; G. Tuveri

Pulmonary fibrosis following low-dose 1,3-bis (2-chloroethyl)-1-nitrosourea (BCNU) therapy

M. Melato, G. Tuveri

IRCCS pediatrico Burlo Garofolo

Research output: Contribution to journal › Article › peer-review

Abstract

Two women, 65 and 55 years old, with metastatic malignant melanoma, were treated with low doses of BCNU for a short period (six and three months, total dose 2500 and 2000 mg). Both patients developed pulmonary fibrosis, which was visible in postmortem examination. In the first woman, lesion development was so widespread as to be considered responsible for death. Because chest x-ray before tractment was not abnormal, the authors consider BCNU capable of inducing the lesion.

Original language	English
Pages (from-to)	1311-1314
Number of pages	4
Journal	Cancer
Volume	45
Issue number	6
Publication status	Published - 1980

ASJC Scopus subject areas

Cancer Research
Oncology

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title = "Pulmonary fibrosis following low-dose 1,3-bis (2-chloroethyl)-1-nitrosourea (BCNU) therapy",

abstract = "Two women, 65 and 55 years old, with metastatic malignant melanoma, were treated with low doses of BCNU for a short period (six and three months, total dose 2500 and 2000 mg). Both patients developed pulmonary fibrosis, which was visible in postmortem examination. In the first woman, lesion development was so widespread as to be considered responsible for death. Because chest x-ray before tractment was not abnormal, the authors consider BCNU capable of inducing the lesion.",

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N2 - Two women, 65 and 55 years old, with metastatic malignant melanoma, were treated with low doses of BCNU for a short period (six and three months, total dose 2500 and 2000 mg). Both patients developed pulmonary fibrosis, which was visible in postmortem examination. In the first woman, lesion development was so widespread as to be considered responsible for death. Because chest x-ray before tractment was not abnormal, the authors consider BCNU capable of inducing the lesion.

AB - Two women, 65 and 55 years old, with metastatic malignant melanoma, were treated with low doses of BCNU for a short period (six and three months, total dose 2500 and 2000 mg). Both patients developed pulmonary fibrosis, which was visible in postmortem examination. In the first woman, lesion development was so widespread as to be considered responsible for death. Because chest x-ray before tractment was not abnormal, the authors consider BCNU capable of inducing the lesion.

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