TY - JOUR
T1 - Pulmonary function in patients surviving to COVID-19 pneumonia
AU - Fumagalli, Alessia
AU - Misuraca, Clementina
AU - Bianchi, Achille
AU - Borsa, Noemi
AU - Limonta, Simone
AU - Maggiolini, Sveva
AU - Bonardi, Daniela Rita
AU - Corsonello, Andrea
AU - Di Rosa, Mirko
AU - Soraci, Luca
AU - Lattanzio, Fabrizia
AU - Colombo, Daniele
N1 - Publisher Copyright:
© 2020, Springer-Verlag GmbH Germany, part of Springer Nature.
Copyright:
Copyright 2021 Elsevier B.V., All rights reserved.
PY - 2021/2
Y1 - 2021/2
N2 - Purpose: The aim of our study was to assess respiratory function at the time of clinical recovery and 6 weeks after discharge in patients surviving to COVID-19 pneumonia. Methods: Our case series consisted of 13 patients with COVID-19 pneumonia. Results: At the time of clinical recovery, FEV1 (2.07 ± 0.72 L) and FVC (2.25 ± 0.86 L) were lower compared to lower limit of normality (LLN) values (2.56 ± 0.53 L, p = 0.004, and 3.31 ± 0.65 L, p < 0.001, respectively), while FEV1/FVC (0.94 ± 0.07) was higher compared to upper limit of normality (ULN) values (0.89 ± 0.01, p = 0.029). After 6 weeks pulmonary function improved but FVC was still lower than ULN (2.87 ± 0.81, p = 0.014). Conclusion: These findings suggest that COVID-19 pneumonia may result in clinically relevant alterations in pulmonary function tests, with a mainly restrictive pattern.
AB - Purpose: The aim of our study was to assess respiratory function at the time of clinical recovery and 6 weeks after discharge in patients surviving to COVID-19 pneumonia. Methods: Our case series consisted of 13 patients with COVID-19 pneumonia. Results: At the time of clinical recovery, FEV1 (2.07 ± 0.72 L) and FVC (2.25 ± 0.86 L) were lower compared to lower limit of normality (LLN) values (2.56 ± 0.53 L, p = 0.004, and 3.31 ± 0.65 L, p < 0.001, respectively), while FEV1/FVC (0.94 ± 0.07) was higher compared to upper limit of normality (ULN) values (0.89 ± 0.01, p = 0.029). After 6 weeks pulmonary function improved but FVC was still lower than ULN (2.87 ± 0.81, p = 0.014). Conclusion: These findings suggest that COVID-19 pneumonia may result in clinically relevant alterations in pulmonary function tests, with a mainly restrictive pattern.
KW - COVID-19
KW - Pneumonia
KW - Spirometry
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U2 - 10.1007/s15010-020-01474-9
DO - 10.1007/s15010-020-01474-9
M3 - Article
C2 - 32725597
AN - SCOPUS:85088808979
VL - 49
SP - 153
EP - 157
JO - Infection
JF - Infection
SN - 0300-8126
IS - 1
ER -