Pulmonary ground-glass opacity: Computed tomography features, histopathology and molecular pathology

Jian Wei Gao, Stefania Rizzo, Li Hong Ma, Xiang Yu Qiu, Arne Warth, Nobuhiko Seki, Mizue Hasegawa, Jia Wei Zou, Qian Li, Marco Femia, Tang Feng Lv, Yong Song, behalf of the AME Lung Cancer Collaborative Group

Research output: Contribution to journalReview articlepeer-review


The incidence of pulmonary ground-glass opacity (GGO) lesions is increasing as a result of the widespread use of multislice spiral computed tomography (CT) and the low-dose CT screening for lung cancer detection. Besides benign lesions, GGOs can be a specific type of lung adenocarcinomas or their preinvasive lesions. Evaluation of pulmonary GGO and investigation of the correlation between CT imaging features and lung adenocarcinoma subtypes or driver genes can be helpful in confirming the diagnosis and in guiding the clinical management. Our review focuses on the pathologic characteristics of GGO detected at CT, involving histopathology and molecular pathology.

Original languageEnglish
Pages (from-to)68-75
Number of pages8
JournalTranslational Lung Cancer Research
Issue number1
Publication statusPublished - Jan 1 2017


  • Anaplastic lymphoma kinase gene (ALK)
  • Computed tomography (CT)
  • Driver genes
  • Epidermal growth factor receptor gene (EGFR)
  • Ground-glass opacity (GGO)
  • Kirsten rat sarcoma viral oncogene homolog (KRAS)
  • Pathology

ASJC Scopus subject areas

  • Oncology


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