Pulmonary haemodynamic and respiratory mechanics in patients with chronic heart failure

M. Volterrani, M. Vitacca, E. Zanelli, E. Clini, C. Scotti, N. Ambrosino, A. Giordano

Research output: Contribution to journalArticlepeer-review


Introduction: Abnormalities in respiratory muscle function and central haemodinamic have been described in chronic heart failure (CHF) patients (pts). Purpose: We evaluated the relationship between pulmonary haemodinamic and respiratory mechanics in these pts. Methods: Seventeen CHF pts (age 62+10; 6 in II, 8 in III, 2 in IV NYHA class) underwent right heart catheterization and simultaneous assessment of respiratory mechanics: PAPtm=pulmonary arterial trasmural pressure, Pwdtm=wedge transmural pressure, occlusion pressure=PO.1, dynamic compliance=CLdyn, pressure time product inspiratory muscles=PTP, max inspiration pressure=MIP, breathing work=WOB, pressure time index=PTI, were assessed at rest and during maximal incremental bycicle exercise test. Results: As expected pts showed, at exercise peak, a significant increase in PWdtm (30±2.5→56±2.5), PAPtm (41±3→72±2), PO.1 (1.1±0.8→3.5±2.1), PTP (164±86→470±134), CLdyn (134±73→97±55), MIP (58±17→44±20), PTI (0.07±0.05→0.2±0.1), WOB (0.7±0.3→2±.08). The relationship between haemodynamic and mechanic parameters are reported in the table. Finally, CLdyn and MIP were significantly related to VO2 peak (r=0.48, p

Original languageEnglish
Issue number4 SUPPL.
Publication statusPublished - Oct 1996

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine


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