Pulmonary Hypertension and Heart Failure: A Dangerous Liaison

Research output: Contribution to journalReview article

2 Citations (Scopus)

Abstract

Pulmonary hypertension (PH) is a common hemodynamic evolution of heart failure (HF) with preserved or reduced ejection fraction, responsible for congestion, symptoms worsening, exercise limitation, and negative outcome. In HF of any origin, PH develops in response to a passive backward pressure transmission as result of increased left atrial pressure. Sustained pressure injury and chronic venous congestion can trigger pulmonary vasoconstriction and vascular remodeling, leading to irreversible pulmonary vascular disease, right ventricular hypertrophy, and failure. In this article, the key determinants of this “dangerous liaison” are analyzed with some digressions on related “leitmotiv” at the horizon.

Original languageEnglish
Pages (from-to)297-309
Number of pages13
JournalHeart Failure Clinics
Volume14
Issue number3
DOIs
Publication statusPublished - Jul 1 2018

Fingerprint

Pulmonary Hypertension
Heart Failure
Right Ventricular Hypertrophy
Pressure
Atrial Pressure
Hyperemia
Vasoconstriction
Vascular Diseases
Lung Diseases
Hemodynamics
Lung
Wounds and Injuries
Vascular Remodeling

Keywords

  • Heart failure
  • Left atrial pressure
  • Mean pulmonary artery pressure
  • Pulmonary hypertension
  • Pulmonary vascular resistance
  • Right heart dysfunction

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Pulmonary Hypertension and Heart Failure : A Dangerous Liaison. / Guazzi, Marco.

In: Heart Failure Clinics, Vol. 14, No. 3, 01.07.2018, p. 297-309.

Research output: Contribution to journalReview article

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