Pulmonary hypertension due to left heart disease

Jean Luc Vachiéry, Ryan J. Tedford, Stephan Rosenkranz, Massimiliano Palazzini, Irene Lang, Marco Guazzi, Gerry Coghlan, Irina Chazova, Teresa De Marco

Research output: Contribution to journalArticlepeer-review


Pulmonary hypertension (PH) is frequent in left heart disease (LHD), as a consequence of the underlying condition. Significant advances have occurred over the past 5 years since the 5th World Symposium on Pulmonary Hypertension in 2013, leading to a better understanding of PH-LHD, challenges and gaps in evidence. PH in heart failure with preserved ejection fraction represents the most complex situation, as it may be misdiagnosed with group 1 PH. Based on the latest evidence, we propose a new haemodynamic definition for PH due to LHD and a three-step pragmatic approach to differential diagnosis. This includes the identification of a specific "left heart" phenotype and a non-invasive probability of PH-LHD. Invasive confirmation of PH-LHD is based on the accurate measurement of pulmonary arterial wedge pressure and, in patients with high probability, provocative testing to clarify the diagnosis. Finally, recent clinical trials did not demonstrate a benefit in treating PH due to LHD with pulmonary arterial hypertension-approved therapies.

Original languageEnglish
JournalThe European respiratory journal
Issue number1
Publication statusPublished - Jan 1 2019

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine


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