Pulmonary interstitial pressure in anesthetized paralyzed newborn rabbits

G. Miserocchi, B. H. Poskurica, M. Del Fabbro

Research output: Contribution to journalArticlepeer-review


In anesthetized paralyzed term newborn rabbits at various postgestational ages (from birth up to 16 days), we measured by micropuncture technique the hydraulic pressure of the pulmonary interstitium (Pip), the extrapleural parietal interstitium, and the pleural liquid. Birth data refer to cesarian- delivered nonbreathing rabbits. Pip increased from 0.5 ± 2 to 6 ± 0.7 cmH2O from birth up to 2 h and then decreased, becoming subatmospheric at 5 h and attaining -6 ± 1.6 cmH2O at 16 days. Over the same period of time, pressure in the extrapleural parietal interstitium and the pleural liquid remained fairly constant at an average value of approximately -1.5 and -2 cmH2O, respectively. The wet-to-dry weight ratio of the lungs decreased from 7.8 ± 0.4 to 4.9 ± 0.1 at 16 days. Plasma protein concentration was 4.2 ± 0.4 g/dl at birth, decreased to 3.2 ± 0.5 g/dl at 1 h from delivery, and increased back to 4 ± 0.6 g/dl at 16 days. Pleural liquid protein concentration was 3 ± 0.1 g/dl at birth and decreased to 1.2 ± 0.2 g/dl at 16 days. In the first hours of postnatal life, the marked increase in Pip appears to be a key factor in favoring fluid clearance from pulmonary interstitium into the pulmonary capillaries and the pleural space. This factor vanishes after ~6 h because of the marked decrease in Pip.

Original languageEnglish
Pages (from-to)2260-2268
Number of pages9
JournalJournal of Applied Physiology
Issue number5
Publication statusPublished - 1994


  • extravascular lung water
  • micropuncture
  • pleural liquid
  • pleural lymphatics
  • pulmonary lymphatics

ASJC Scopus subject areas

  • Physiology
  • Endocrinology
  • Orthopedics and Sports Medicine
  • Physical Therapy, Sports Therapy and Rehabilitation


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