Pulmonary interstitial pressure in premature rabbits

Giuseppe Miserocchi, Besa Haxhiu Poskurica, Massimo del Fabbro, Beatrice Crisafulli

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

By micropuncture technique we measured pulmonary interstitial pressuure (Pip) from birth up to 6 h postnatal age in anesthetized and paralyzed cesarian delivered term (31 days gestation) and premature (27 to 30 days gestation) rabbits. In term cesarian delivered rabbits Pip followed the time course of vaginally delivered rabbits, namely, it increased from about zero at birth up to about 5 cmH2O at 2 h, as a result of alveolar fluid reabsorption, subsequently it decreased becoming subatmospheric due to progressive interstitial fluid drainage. In ventilated lung regions of premature rabbits, Pip also peaked to about 5 cmH2O at 2 h but its subsequent decrease was markedly slowed down while in atelectatic regions of premature rabbits Pip remained slightly subatmospheric. Up to 6 h, the wet/dry weight ratio of the lung was higher in premature relative to vaginally and cesarian delivered term rabbits (at birth 8.4 ± 0.9 vs. 7.5 ± 0.8). In 29-31 days rabbits, plasma protein concentration at birth was 3.6 ± 0.5 g/dl (within 95% confidence limits for vaginally delivered rabbits, considered as control) while in 27-28 days rabbit it was 3.1 ± 0.4 g/dl (at the lower edge of control confidence limits). In the first postnatal hours, the increase in Pip favoured fluid reabsorption into pulmonary microcirculation in term cesarian delivered rabbits and in ventilated regions of premature rabbits. Conversely, in the atelectatic regions of premature rabbits the unchanged Pip value in the postnatal hours favours fluid filtration from microcirculation into lung interstitium.

Original languageEnglish
Pages (from-to)239-249
Number of pages11
JournalRespiration Physiology
Volume102
Issue number2-3
DOIs
Publication statusPublished - 1995

Fingerprint

Rabbits
Pressure
Lung
Parturition
Microcirculation
Pregnancy
Extracellular Fluid
Punctures
Blood Proteins
Drainage
Weights and Measures

Keywords

  • Development, interstitial pressure at birth
  • Mammals, rabbit
  • Pressure, interstitial, at birth
  • Water, extravascular lung

ASJC Scopus subject areas

  • Physiology
  • Pulmonary and Respiratory Medicine

Cite this

Pulmonary interstitial pressure in premature rabbits. / Miserocchi, Giuseppe; Poskurica, Besa Haxhiu; del Fabbro, Massimo; Crisafulli, Beatrice.

In: Respiration Physiology, Vol. 102, No. 2-3, 1995, p. 239-249.

Research output: Contribution to journalArticle

Miserocchi, G, Poskurica, BH, del Fabbro, M & Crisafulli, B 1995, 'Pulmonary interstitial pressure in premature rabbits', Respiration Physiology, vol. 102, no. 2-3, pp. 239-249. https://doi.org/10.1016/0034-5687(95)00070-4
Miserocchi, Giuseppe ; Poskurica, Besa Haxhiu ; del Fabbro, Massimo ; Crisafulli, Beatrice. / Pulmonary interstitial pressure in premature rabbits. In: Respiration Physiology. 1995 ; Vol. 102, No. 2-3. pp. 239-249.
@article{2e8a2ea66d174d2fb9093ed148d6329e,
title = "Pulmonary interstitial pressure in premature rabbits",
abstract = "By micropuncture technique we measured pulmonary interstitial pressuure (Pip) from birth up to 6 h postnatal age in anesthetized and paralyzed cesarian delivered term (31 days gestation) and premature (27 to 30 days gestation) rabbits. In term cesarian delivered rabbits Pip followed the time course of vaginally delivered rabbits, namely, it increased from about zero at birth up to about 5 cmH2O at 2 h, as a result of alveolar fluid reabsorption, subsequently it decreased becoming subatmospheric due to progressive interstitial fluid drainage. In ventilated lung regions of premature rabbits, Pip also peaked to about 5 cmH2O at 2 h but its subsequent decrease was markedly slowed down while in atelectatic regions of premature rabbits Pip remained slightly subatmospheric. Up to 6 h, the wet/dry weight ratio of the lung was higher in premature relative to vaginally and cesarian delivered term rabbits (at birth 8.4 ± 0.9 vs. 7.5 ± 0.8). In 29-31 days rabbits, plasma protein concentration at birth was 3.6 ± 0.5 g/dl (within 95{\%} confidence limits for vaginally delivered rabbits, considered as control) while in 27-28 days rabbit it was 3.1 ± 0.4 g/dl (at the lower edge of control confidence limits). In the first postnatal hours, the increase in Pip favoured fluid reabsorption into pulmonary microcirculation in term cesarian delivered rabbits and in ventilated regions of premature rabbits. Conversely, in the atelectatic regions of premature rabbits the unchanged Pip value in the postnatal hours favours fluid filtration from microcirculation into lung interstitium.",
keywords = "Development, interstitial pressure at birth, Mammals, rabbit, Pressure, interstitial, at birth, Water, extravascular lung",
author = "Giuseppe Miserocchi and Poskurica, {Besa Haxhiu} and {del Fabbro}, Massimo and Beatrice Crisafulli",
year = "1995",
doi = "10.1016/0034-5687(95)00070-4",
language = "English",
volume = "102",
pages = "239--249",
journal = "Respiration Physiology",
issn = "0034-5687",
publisher = "Elsevier BV",
number = "2-3",

}

TY - JOUR

T1 - Pulmonary interstitial pressure in premature rabbits

AU - Miserocchi, Giuseppe

AU - Poskurica, Besa Haxhiu

AU - del Fabbro, Massimo

AU - Crisafulli, Beatrice

PY - 1995

Y1 - 1995

N2 - By micropuncture technique we measured pulmonary interstitial pressuure (Pip) from birth up to 6 h postnatal age in anesthetized and paralyzed cesarian delivered term (31 days gestation) and premature (27 to 30 days gestation) rabbits. In term cesarian delivered rabbits Pip followed the time course of vaginally delivered rabbits, namely, it increased from about zero at birth up to about 5 cmH2O at 2 h, as a result of alveolar fluid reabsorption, subsequently it decreased becoming subatmospheric due to progressive interstitial fluid drainage. In ventilated lung regions of premature rabbits, Pip also peaked to about 5 cmH2O at 2 h but its subsequent decrease was markedly slowed down while in atelectatic regions of premature rabbits Pip remained slightly subatmospheric. Up to 6 h, the wet/dry weight ratio of the lung was higher in premature relative to vaginally and cesarian delivered term rabbits (at birth 8.4 ± 0.9 vs. 7.5 ± 0.8). In 29-31 days rabbits, plasma protein concentration at birth was 3.6 ± 0.5 g/dl (within 95% confidence limits for vaginally delivered rabbits, considered as control) while in 27-28 days rabbit it was 3.1 ± 0.4 g/dl (at the lower edge of control confidence limits). In the first postnatal hours, the increase in Pip favoured fluid reabsorption into pulmonary microcirculation in term cesarian delivered rabbits and in ventilated regions of premature rabbits. Conversely, in the atelectatic regions of premature rabbits the unchanged Pip value in the postnatal hours favours fluid filtration from microcirculation into lung interstitium.

AB - By micropuncture technique we measured pulmonary interstitial pressuure (Pip) from birth up to 6 h postnatal age in anesthetized and paralyzed cesarian delivered term (31 days gestation) and premature (27 to 30 days gestation) rabbits. In term cesarian delivered rabbits Pip followed the time course of vaginally delivered rabbits, namely, it increased from about zero at birth up to about 5 cmH2O at 2 h, as a result of alveolar fluid reabsorption, subsequently it decreased becoming subatmospheric due to progressive interstitial fluid drainage. In ventilated lung regions of premature rabbits, Pip also peaked to about 5 cmH2O at 2 h but its subsequent decrease was markedly slowed down while in atelectatic regions of premature rabbits Pip remained slightly subatmospheric. Up to 6 h, the wet/dry weight ratio of the lung was higher in premature relative to vaginally and cesarian delivered term rabbits (at birth 8.4 ± 0.9 vs. 7.5 ± 0.8). In 29-31 days rabbits, plasma protein concentration at birth was 3.6 ± 0.5 g/dl (within 95% confidence limits for vaginally delivered rabbits, considered as control) while in 27-28 days rabbit it was 3.1 ± 0.4 g/dl (at the lower edge of control confidence limits). In the first postnatal hours, the increase in Pip favoured fluid reabsorption into pulmonary microcirculation in term cesarian delivered rabbits and in ventilated regions of premature rabbits. Conversely, in the atelectatic regions of premature rabbits the unchanged Pip value in the postnatal hours favours fluid filtration from microcirculation into lung interstitium.

KW - Development, interstitial pressure at birth

KW - Mammals, rabbit

KW - Pressure, interstitial, at birth

KW - Water, extravascular lung

UR - http://www.scopus.com/inward/record.url?scp=0029589585&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0029589585&partnerID=8YFLogxK

U2 - 10.1016/0034-5687(95)00070-4

DO - 10.1016/0034-5687(95)00070-4

M3 - Article

C2 - 8904015

AN - SCOPUS:0029589585

VL - 102

SP - 239

EP - 249

JO - Respiration Physiology

JF - Respiration Physiology

SN - 0034-5687

IS - 2-3

ER -