Abstract
By micropuncture technique we measured pulmonary interstitial pressuure (Pip) from birth up to 6 h postnatal age in anesthetized and paralyzed cesarian delivered term (31 days gestation) and premature (27 to 30 days gestation) rabbits. In term cesarian delivered rabbits Pip followed the time course of vaginally delivered rabbits, namely, it increased from about zero at birth up to about 5 cmH2O at 2 h, as a result of alveolar fluid reabsorption, subsequently it decreased becoming subatmospheric due to progressive interstitial fluid drainage. In ventilated lung regions of premature rabbits, Pip also peaked to about 5 cmH2O at 2 h but its subsequent decrease was markedly slowed down while in atelectatic regions of premature rabbits Pip remained slightly subatmospheric. Up to 6 h, the wet/dry weight ratio of the lung was higher in premature relative to vaginally and cesarian delivered term rabbits (at birth 8.4 ± 0.9 vs. 7.5 ± 0.8). In 29-31 days rabbits, plasma protein concentration at birth was 3.6 ± 0.5 g/dl (within 95% confidence limits for vaginally delivered rabbits, considered as control) while in 27-28 days rabbit it was 3.1 ± 0.4 g/dl (at the lower edge of control confidence limits). In the first postnatal hours, the increase in Pip favoured fluid reabsorption into pulmonary microcirculation in term cesarian delivered rabbits and in ventilated regions of premature rabbits. Conversely, in the atelectatic regions of premature rabbits the unchanged Pip value in the postnatal hours favours fluid filtration from microcirculation into lung interstitium.
| Original language | English |
|---|---|
| Pages (from-to) | 239-249 |
| Number of pages | 11 |
| Journal | Respiration Physiology |
| Volume | 102 |
| Issue number | 2-3 |
| DOIs | |
| Publication status | Published - 1995 |
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Keywords
- Development, interstitial pressure at birth
- Mammals, rabbit
- Pressure, interstitial, at birth
- Water, extravascular lung
ASJC Scopus subject areas
- Physiology
- Pulmonary and Respiratory Medicine
Cite this
Pulmonary interstitial pressure in premature rabbits. / Miserocchi, Giuseppe; Poskurica, Besa Haxhiu; del Fabbro, Massimo; Crisafulli, Beatrice.
In: Respiration Physiology, Vol. 102, No. 2-3, 1995, p. 239-249.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Pulmonary interstitial pressure in premature rabbits
AU - Miserocchi, Giuseppe
AU - Poskurica, Besa Haxhiu
AU - del Fabbro, Massimo
AU - Crisafulli, Beatrice
PY - 1995
Y1 - 1995
N2 - By micropuncture technique we measured pulmonary interstitial pressuure (Pip) from birth up to 6 h postnatal age in anesthetized and paralyzed cesarian delivered term (31 days gestation) and premature (27 to 30 days gestation) rabbits. In term cesarian delivered rabbits Pip followed the time course of vaginally delivered rabbits, namely, it increased from about zero at birth up to about 5 cmH2O at 2 h, as a result of alveolar fluid reabsorption, subsequently it decreased becoming subatmospheric due to progressive interstitial fluid drainage. In ventilated lung regions of premature rabbits, Pip also peaked to about 5 cmH2O at 2 h but its subsequent decrease was markedly slowed down while in atelectatic regions of premature rabbits Pip remained slightly subatmospheric. Up to 6 h, the wet/dry weight ratio of the lung was higher in premature relative to vaginally and cesarian delivered term rabbits (at birth 8.4 ± 0.9 vs. 7.5 ± 0.8). In 29-31 days rabbits, plasma protein concentration at birth was 3.6 ± 0.5 g/dl (within 95% confidence limits for vaginally delivered rabbits, considered as control) while in 27-28 days rabbit it was 3.1 ± 0.4 g/dl (at the lower edge of control confidence limits). In the first postnatal hours, the increase in Pip favoured fluid reabsorption into pulmonary microcirculation in term cesarian delivered rabbits and in ventilated regions of premature rabbits. Conversely, in the atelectatic regions of premature rabbits the unchanged Pip value in the postnatal hours favours fluid filtration from microcirculation into lung interstitium.
AB - By micropuncture technique we measured pulmonary interstitial pressuure (Pip) from birth up to 6 h postnatal age in anesthetized and paralyzed cesarian delivered term (31 days gestation) and premature (27 to 30 days gestation) rabbits. In term cesarian delivered rabbits Pip followed the time course of vaginally delivered rabbits, namely, it increased from about zero at birth up to about 5 cmH2O at 2 h, as a result of alveolar fluid reabsorption, subsequently it decreased becoming subatmospheric due to progressive interstitial fluid drainage. In ventilated lung regions of premature rabbits, Pip also peaked to about 5 cmH2O at 2 h but its subsequent decrease was markedly slowed down while in atelectatic regions of premature rabbits Pip remained slightly subatmospheric. Up to 6 h, the wet/dry weight ratio of the lung was higher in premature relative to vaginally and cesarian delivered term rabbits (at birth 8.4 ± 0.9 vs. 7.5 ± 0.8). In 29-31 days rabbits, plasma protein concentration at birth was 3.6 ± 0.5 g/dl (within 95% confidence limits for vaginally delivered rabbits, considered as control) while in 27-28 days rabbit it was 3.1 ± 0.4 g/dl (at the lower edge of control confidence limits). In the first postnatal hours, the increase in Pip favoured fluid reabsorption into pulmonary microcirculation in term cesarian delivered rabbits and in ventilated regions of premature rabbits. Conversely, in the atelectatic regions of premature rabbits the unchanged Pip value in the postnatal hours favours fluid filtration from microcirculation into lung interstitium.
KW - Development, interstitial pressure at birth
KW - Mammals, rabbit
KW - Pressure, interstitial, at birth
KW - Water, extravascular lung
UR - http://www.scopus.com/inward/record.url?scp=0029589585&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0029589585&partnerID=8YFLogxK
U2 - 10.1016/0034-5687(95)00070-4
DO - 10.1016/0034-5687(95)00070-4
M3 - Article
C2 - 8904015
AN - SCOPUS:0029589585
VL - 102
SP - 239
EP - 249
JO - Respiration Physiology
JF - Respiration Physiology
SN - 0034-5687
IS - 2-3
ER -