Pulmonary microsporidiosis due to Encephalitozoon hellem in a patient with AIDS

M. Scaglia; L. Sacchi; G. P. Croppo; A. Da Silva; S. Gatti; S. Corona; A. Orani; A. M. Bernuzzi; N. J. Pieniazek; S. B. Slemenda; S. Wallace; G. S. Visvesvara

Pulmonary microsporidiosis due to Encephalitozoon hellem in a patient with AIDS

M. Scaglia, L. Sacchi, G. P. Croppo, A. Da Silva, S. Gatti, S. Corona, A. Orani, A. M. Bernuzzi, N. J. Pieniazek, S. B. Slemenda, S. Wallace, G. S. Visvesvara

IRCCS Fondazione Policlinico San Matteo

Research output: Contribution to journal › Article

Abstract

The microsporidium Encephalitozoon hellem is being reported with increasingly frequency in HIV-positive subjects, as an agent of disseminated microsporidiosis without involving the gastrointestinal tract. We describe a case of pulmonary microsporidiosis in a 27-year-old Italian man with AIDS who developed fever, cough, and dyspnea. A chest X-ray showed multiple bilateral pulmonary opacities and mediastinal lymph-node enlargement. Stained smears of bronchoalveolar lavage sediment showed oval structures consistent with microsporidium spores. Viral, bacterial and fungal cultures were repeatedly negative, whereas microsporidia were successfully cultured in human and bovine fibroblast cell lines. Analysis of electron micrographs indicated that the isolate belonged to the genus Encephalitozoon. Based on further immunological, biochemical and molecular studies it was characterized as E. hellem. Even though a temporary improvement with albendazole therapy was noticed, the patient deteriorated clinically and died of severe respiratory distress.

Original language	English
Pages (from-to)	119-126
Number of pages	8
Journal	Journal of Infection
Volume	34
Issue number	2
Publication status	Published - 1997

ASJC Scopus subject areas

Applied Microbiology and Biotechnology
Microbiology
Parasitology
Virology
Immunology and Allergy
Infectious Diseases

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Scaglia, M., Sacchi, L., Croppo, G. P., Da Silva, A., Gatti, S., Corona, S., Orani, A., Bernuzzi, A. M., Pieniazek, N. J., Slemenda, S. B., Wallace, S., & Visvesvara, G. S. (1997). Pulmonary microsporidiosis due to Encephalitozoon hellem in a patient with AIDS. Journal of Infection, 34(2), 119-126.

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title = "Pulmonary microsporidiosis due to Encephalitozoon hellem in a patient with AIDS",

abstract = "The microsporidium Encephalitozoon hellem is being reported with increasingly frequency in HIV-positive subjects, as an agent of disseminated microsporidiosis without involving the gastrointestinal tract. We describe a case of pulmonary microsporidiosis in a 27-year-old Italian man with AIDS who developed fever, cough, and dyspnea. A chest X-ray showed multiple bilateral pulmonary opacities and mediastinal lymph-node enlargement. Stained smears of bronchoalveolar lavage sediment showed oval structures consistent with microsporidium spores. Viral, bacterial and fungal cultures were repeatedly negative, whereas microsporidia were successfully cultured in human and bovine fibroblast cell lines. Analysis of electron micrographs indicated that the isolate belonged to the genus Encephalitozoon. Based on further immunological, biochemical and molecular studies it was characterized as E. hellem. Even though a temporary improvement with albendazole therapy was noticed, the patient deteriorated clinically and died of severe respiratory distress.",

author = "M. Scaglia and L. Sacchi and Croppo, {G. P.} and {Da Silva}, A. and S. Gatti and S. Corona and A. Orani and Bernuzzi, {A. M.} and Pieniazek, {N. J.} and Slemenda, {S. B.} and S. Wallace and Visvesvara, {G. S.}",

year = "1997",

language = "English",

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pages = "119--126",

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AU - Scaglia, M.

AU - Sacchi, L.

AU - Croppo, G. P.

AU - Da Silva, A.

AU - Gatti, S.

AU - Corona, S.

AU - Orani, A.

AU - Bernuzzi, A. M.

AU - Pieniazek, N. J.

AU - Slemenda, S. B.

AU - Wallace, S.

AU - Visvesvara, G. S.

PY - 1997

Y1 - 1997

N2 - The microsporidium Encephalitozoon hellem is being reported with increasingly frequency in HIV-positive subjects, as an agent of disseminated microsporidiosis without involving the gastrointestinal tract. We describe a case of pulmonary microsporidiosis in a 27-year-old Italian man with AIDS who developed fever, cough, and dyspnea. A chest X-ray showed multiple bilateral pulmonary opacities and mediastinal lymph-node enlargement. Stained smears of bronchoalveolar lavage sediment showed oval structures consistent with microsporidium spores. Viral, bacterial and fungal cultures were repeatedly negative, whereas microsporidia were successfully cultured in human and bovine fibroblast cell lines. Analysis of electron micrographs indicated that the isolate belonged to the genus Encephalitozoon. Based on further immunological, biochemical and molecular studies it was characterized as E. hellem. Even though a temporary improvement with albendazole therapy was noticed, the patient deteriorated clinically and died of severe respiratory distress.

AB - The microsporidium Encephalitozoon hellem is being reported with increasingly frequency in HIV-positive subjects, as an agent of disseminated microsporidiosis without involving the gastrointestinal tract. We describe a case of pulmonary microsporidiosis in a 27-year-old Italian man with AIDS who developed fever, cough, and dyspnea. A chest X-ray showed multiple bilateral pulmonary opacities and mediastinal lymph-node enlargement. Stained smears of bronchoalveolar lavage sediment showed oval structures consistent with microsporidium spores. Viral, bacterial and fungal cultures were repeatedly negative, whereas microsporidia were successfully cultured in human and bovine fibroblast cell lines. Analysis of electron micrographs indicated that the isolate belonged to the genus Encephalitozoon. Based on further immunological, biochemical and molecular studies it was characterized as E. hellem. Even though a temporary improvement with albendazole therapy was noticed, the patient deteriorated clinically and died of severe respiratory distress.

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