Pulmonary O2 diffusing capacity at exercise by a modified rebreathing method

A. Veicsteinas, H. Magnussen, M. Meyer, P. Cerretelli

Research output: Contribution to journalArticlepeer-review


The rebreathing technique for the measurement of the pulmonary O2 diffusing capacity, {Mathematical expression}, previously developed for resting conditions [Cerretelli et al., J. appl. Physiol. 37, 526-532 (1974)] has been modified for application to exercise and simplified to one rebreathing maneuver only. The changes consist: 1) in administering in the course of a normoxic exercise a priming breath of an O2 free mixture just before the onset of rebreathing in order to achieve rapidly the appropriate starting {Mathematical expression} values on the linear part of the O2 dissociation curve as required by the method; 2) in calculating mixed venous blood O2 tension by extrapolation of the alveolar to mixed venous blood {Mathematical expression} equilibration curve, instead of determining it separately. While the mean {Mathematical expression} value of 21 measurements on 5 subjects at rest was 30 ml·min-1·Torr-1±3 (S.E.), in 2 subjects exercising on a bicycle ergometer, {Mathematical expression} was found to increase from a resting value of about 32 ml·min-1·Torr-1 to 107 ml·min-1·Torr-1 for an eightfold increase of O2 uptake. The validity and the applicability of the method are critically discussed.

Original languageEnglish
Pages (from-to)79-88
Number of pages10
JournalEuropean Journal of Applied Physiology and Occupational Physiology
Issue number1
Publication statusPublished - Mar 1976


  • Alveolar-capillary equilibration
  • Exercise
  • Pulmonary blood flow
  • Pulmonary diffusing capacity
  • Rebreathing

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health
  • Physiology


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