Pulmonary squamous cell carcinoma with lepidic growth pattern: New insights into lung cancer classification

Alessandro Del Gobbo, Andrea Vingiani, Emilia Masci, Giuseppe Faillace, Salvatore Barbaro, Eleonora Bonaparte, Stefano Ferrero

Research output: Contribution to journalArticle

Abstract

Lung squamous cell carcinoma (SCC) has always been considered a monomorphic entity, different from lung adenocarcinoma which is known to be a very heterogeneous tumor from morphological and molecular point of view. Just two histological subtypes of SCC are recognised, the basaloid and lymphoepithelioma-like histotypes, as in other sites different from the lung. Recently, different studies tried to expand the classification of SCC by adding different subtypes based on morphological characteristics (such as keratinization or clear cell features) or different growth patterns (papillary or basaloid). We report a case of squamous cell carcinoma with a previously unreported, distinctive and predominant "lepidic" growth pattern, with its immunophenotypical and molecular characterization.

Original languageEnglish
Pages (from-to)7668-7673
Number of pages6
JournalInternational Journal of Clinical and Experimental Pathology
Volume9
Issue number7
Publication statusPublished - 2016

Keywords

  • Lepidic growth pattern
  • Lung pathology
  • Squamous cell carcinoma

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Histology

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    Del Gobbo, A., Vingiani, A., Masci, E., Faillace, G., Barbaro, S., Bonaparte, E., & Ferrero, S. (2016). Pulmonary squamous cell carcinoma with lepidic growth pattern: New insights into lung cancer classification. International Journal of Clinical and Experimental Pathology, 9(7), 7668-7673.