Pulmonary vascular function and aerobic exercise capacity at moderate altitude

Vitalie Faoro, Gael Deboeck, Marco Vicenzi, Anne Fleur Gaston, Bamodi Simaga, Grégory Doucende, Ilona Hapkova, Emma Roca, Enric Subirats, Fabienne Durand, Robert Naeije

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Purpose There has been suggestion that a greater "pulmonary vascular reserve" defined by a low pulmonary vascular resistance (PVR) and a high lung diffusing capacity (DL) allow for a superior aerobic exercise capacity. How pulmonary vascular reserve might affect exercise capacity at moderate altitude is not known. Methods Thirty-eight healthy subjects underwent an exercise stress echocardiography of the pulmonary circulation, combined with measurements of DL for nitric oxide (NO) and carbon monoxide (CO) and a cardiopulmonary exercise test at sea level and at an altitude of 2250 m. Results At rest, moderate altitude decreased arterial oxygen content (CaO2) from 19.1 ± 1.6 to 18.4 ± 1.7 mL·dL-1, P < 0.001, and slightly increased PVR, DLNO, and DLCO. Exercise at moderate altitude was associated with decreases in maximum O2 uptake (VO2max), from 51 ± 9 to 43 ± 8 mL·kg-1⋅min-1, P < 0.001, and CaO2 to 16.5 ± 1.7 mL·dL-1, P < 0.001, but no different cardiac output, PVR, and pulmonary vascular distensibility. DLNO was inversely correlated to the ventilatory equivalent of CO2 (VE/VCO2) at sea level and at moderate altitude. Independent determinants of VO2max as determined by a multivariable analysis were the slope of mean pulmonary artery pressure-cardiac output relationship, resting stroke volume, and resting DLNO at sea level as well as at moderate altitude. The magnitude of the decrease in VO2max at moderate altitude was independently predicted by more pronounced exercise-induced decrease in CaO2 at moderate altitude. Conclusion Aerobic exercise capacity is similarly modulated by pulmonary vascular reserve at moderate altitude and at sea level. Decreased aerobic exercise capacity at moderate altitude is mainly explained by exercise-induced decrease in arterial oxygenation.

Original languageEnglish
Pages (from-to)2131-2138
Number of pages8
JournalMedicine and Science in Sports and Exercise
Volume49
Issue number10
DOIs
Publication statusPublished - Oct 1 2017
Externally publishedYes

Fingerprint

Blood Vessels
Exercise
Lung
Oceans and Seas
Vascular Resistance
Cardiac Output
Lung Volume Measurements
Stress Echocardiography
Pulmonary Circulation
Carbon Monoxide
Exercise Test
Stroke Volume
Pulmonary Artery
Healthy Volunteers
Nitric Oxide
Oxygen
Pressure

Keywords

  • HYPOXIA
  • LUNG DIFFUSING CAPACITY
  • PULMONARY CIRCULATION
  • PULMONARY VASCULAR RESISTANCE
  • VO

ASJC Scopus subject areas

  • Orthopedics and Sports Medicine
  • Physical Therapy, Sports Therapy and Rehabilitation

Cite this

Faoro, V., Deboeck, G., Vicenzi, M., Gaston, A. F., Simaga, B., Doucende, G., ... Naeije, R. (2017). Pulmonary vascular function and aerobic exercise capacity at moderate altitude. Medicine and Science in Sports and Exercise, 49(10), 2131-2138. https://doi.org/10.1249/MSS.0000000000001320

Pulmonary vascular function and aerobic exercise capacity at moderate altitude. / Faoro, Vitalie; Deboeck, Gael; Vicenzi, Marco; Gaston, Anne Fleur; Simaga, Bamodi; Doucende, Grégory; Hapkova, Ilona; Roca, Emma; Subirats, Enric; Durand, Fabienne; Naeije, Robert.

In: Medicine and Science in Sports and Exercise, Vol. 49, No. 10, 01.10.2017, p. 2131-2138.

Research output: Contribution to journalArticle

Faoro, V, Deboeck, G, Vicenzi, M, Gaston, AF, Simaga, B, Doucende, G, Hapkova, I, Roca, E, Subirats, E, Durand, F & Naeije, R 2017, 'Pulmonary vascular function and aerobic exercise capacity at moderate altitude', Medicine and Science in Sports and Exercise, vol. 49, no. 10, pp. 2131-2138. https://doi.org/10.1249/MSS.0000000000001320
Faoro, Vitalie ; Deboeck, Gael ; Vicenzi, Marco ; Gaston, Anne Fleur ; Simaga, Bamodi ; Doucende, Grégory ; Hapkova, Ilona ; Roca, Emma ; Subirats, Enric ; Durand, Fabienne ; Naeije, Robert. / Pulmonary vascular function and aerobic exercise capacity at moderate altitude. In: Medicine and Science in Sports and Exercise. 2017 ; Vol. 49, No. 10. pp. 2131-2138.
@article{2c4aafa479c8456b8d04aa0506f391b6,
title = "Pulmonary vascular function and aerobic exercise capacity at moderate altitude",
abstract = "Purpose There has been suggestion that a greater {"}pulmonary vascular reserve{"} defined by a low pulmonary vascular resistance (PVR) and a high lung diffusing capacity (DL) allow for a superior aerobic exercise capacity. How pulmonary vascular reserve might affect exercise capacity at moderate altitude is not known. Methods Thirty-eight healthy subjects underwent an exercise stress echocardiography of the pulmonary circulation, combined with measurements of DL for nitric oxide (NO) and carbon monoxide (CO) and a cardiopulmonary exercise test at sea level and at an altitude of 2250 m. Results At rest, moderate altitude decreased arterial oxygen content (CaO2) from 19.1 ± 1.6 to 18.4 ± 1.7 mL·dL-1, P < 0.001, and slightly increased PVR, DLNO, and DLCO. Exercise at moderate altitude was associated with decreases in maximum O2 uptake (VO2max), from 51 ± 9 to 43 ± 8 mL·kg-1⋅min-1, P < 0.001, and CaO2 to 16.5 ± 1.7 mL·dL-1, P < 0.001, but no different cardiac output, PVR, and pulmonary vascular distensibility. DLNO was inversely correlated to the ventilatory equivalent of CO2 (VE/VCO2) at sea level and at moderate altitude. Independent determinants of VO2max as determined by a multivariable analysis were the slope of mean pulmonary artery pressure-cardiac output relationship, resting stroke volume, and resting DLNO at sea level as well as at moderate altitude. The magnitude of the decrease in VO2max at moderate altitude was independently predicted by more pronounced exercise-induced decrease in CaO2 at moderate altitude. Conclusion Aerobic exercise capacity is similarly modulated by pulmonary vascular reserve at moderate altitude and at sea level. Decreased aerobic exercise capacity at moderate altitude is mainly explained by exercise-induced decrease in arterial oxygenation.",
keywords = "HYPOXIA, LUNG DIFFUSING CAPACITY, PULMONARY CIRCULATION, PULMONARY VASCULAR RESISTANCE, VO",
author = "Vitalie Faoro and Gael Deboeck and Marco Vicenzi and Gaston, {Anne Fleur} and Bamodi Simaga and Gr{\'e}gory Doucende and Ilona Hapkova and Emma Roca and Enric Subirats and Fabienne Durand and Robert Naeije",
year = "2017",
month = "10",
day = "1",
doi = "10.1249/MSS.0000000000001320",
language = "English",
volume = "49",
pages = "2131--2138",
journal = "Medicine and Science in Sports and Exercise",
issn = "0195-9131",
publisher = "Lippincott Williams and Wilkins",
number = "10",

}

TY - JOUR

T1 - Pulmonary vascular function and aerobic exercise capacity at moderate altitude

AU - Faoro, Vitalie

AU - Deboeck, Gael

AU - Vicenzi, Marco

AU - Gaston, Anne Fleur

AU - Simaga, Bamodi

AU - Doucende, Grégory

AU - Hapkova, Ilona

AU - Roca, Emma

AU - Subirats, Enric

AU - Durand, Fabienne

AU - Naeije, Robert

PY - 2017/10/1

Y1 - 2017/10/1

N2 - Purpose There has been suggestion that a greater "pulmonary vascular reserve" defined by a low pulmonary vascular resistance (PVR) and a high lung diffusing capacity (DL) allow for a superior aerobic exercise capacity. How pulmonary vascular reserve might affect exercise capacity at moderate altitude is not known. Methods Thirty-eight healthy subjects underwent an exercise stress echocardiography of the pulmonary circulation, combined with measurements of DL for nitric oxide (NO) and carbon monoxide (CO) and a cardiopulmonary exercise test at sea level and at an altitude of 2250 m. Results At rest, moderate altitude decreased arterial oxygen content (CaO2) from 19.1 ± 1.6 to 18.4 ± 1.7 mL·dL-1, P < 0.001, and slightly increased PVR, DLNO, and DLCO. Exercise at moderate altitude was associated with decreases in maximum O2 uptake (VO2max), from 51 ± 9 to 43 ± 8 mL·kg-1⋅min-1, P < 0.001, and CaO2 to 16.5 ± 1.7 mL·dL-1, P < 0.001, but no different cardiac output, PVR, and pulmonary vascular distensibility. DLNO was inversely correlated to the ventilatory equivalent of CO2 (VE/VCO2) at sea level and at moderate altitude. Independent determinants of VO2max as determined by a multivariable analysis were the slope of mean pulmonary artery pressure-cardiac output relationship, resting stroke volume, and resting DLNO at sea level as well as at moderate altitude. The magnitude of the decrease in VO2max at moderate altitude was independently predicted by more pronounced exercise-induced decrease in CaO2 at moderate altitude. Conclusion Aerobic exercise capacity is similarly modulated by pulmonary vascular reserve at moderate altitude and at sea level. Decreased aerobic exercise capacity at moderate altitude is mainly explained by exercise-induced decrease in arterial oxygenation.

AB - Purpose There has been suggestion that a greater "pulmonary vascular reserve" defined by a low pulmonary vascular resistance (PVR) and a high lung diffusing capacity (DL) allow for a superior aerobic exercise capacity. How pulmonary vascular reserve might affect exercise capacity at moderate altitude is not known. Methods Thirty-eight healthy subjects underwent an exercise stress echocardiography of the pulmonary circulation, combined with measurements of DL for nitric oxide (NO) and carbon monoxide (CO) and a cardiopulmonary exercise test at sea level and at an altitude of 2250 m. Results At rest, moderate altitude decreased arterial oxygen content (CaO2) from 19.1 ± 1.6 to 18.4 ± 1.7 mL·dL-1, P < 0.001, and slightly increased PVR, DLNO, and DLCO. Exercise at moderate altitude was associated with decreases in maximum O2 uptake (VO2max), from 51 ± 9 to 43 ± 8 mL·kg-1⋅min-1, P < 0.001, and CaO2 to 16.5 ± 1.7 mL·dL-1, P < 0.001, but no different cardiac output, PVR, and pulmonary vascular distensibility. DLNO was inversely correlated to the ventilatory equivalent of CO2 (VE/VCO2) at sea level and at moderate altitude. Independent determinants of VO2max as determined by a multivariable analysis were the slope of mean pulmonary artery pressure-cardiac output relationship, resting stroke volume, and resting DLNO at sea level as well as at moderate altitude. The magnitude of the decrease in VO2max at moderate altitude was independently predicted by more pronounced exercise-induced decrease in CaO2 at moderate altitude. Conclusion Aerobic exercise capacity is similarly modulated by pulmonary vascular reserve at moderate altitude and at sea level. Decreased aerobic exercise capacity at moderate altitude is mainly explained by exercise-induced decrease in arterial oxygenation.

KW - HYPOXIA

KW - LUNG DIFFUSING CAPACITY

KW - PULMONARY CIRCULATION

KW - PULMONARY VASCULAR RESISTANCE

KW - VO

UR - http://www.scopus.com/inward/record.url?scp=85032512436&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85032512436&partnerID=8YFLogxK

U2 - 10.1249/MSS.0000000000001320

DO - 10.1249/MSS.0000000000001320

M3 - Article

VL - 49

SP - 2131

EP - 2138

JO - Medicine and Science in Sports and Exercise

JF - Medicine and Science in Sports and Exercise

SN - 0195-9131

IS - 10

ER -