Pulmonary Vein Denervation Enhances Long-Term Benefit after Circumferential Ablation for Paroxysmal Atrial Fibrillation

Carlo Pappone, Vincenzo Santinelli, Francesco Manguso, Gabriele Vicedomini, Filippo Gugliotta, Giuseppe Augello, Patrizio Mazzone, Valter Tortoriello, Giovanni Landoni, Alberto Zangrillo, Christopher Lang, Takeshi Tomita, Cézar Mesas, Elio Mastella, Ottavio Alfieri

Research output: Contribution to journalArticle

Abstract

Background-There are no data to evaluate the relationship between autonomic nerve function modification and recurrent atrial fibrillation (AF) after circumferential pulmonary vein ablation (CPVA). This study assesses the incremental benefit of vagal denervation by radiofrequency in preventing recurrent AF in a large series of patients undergoing CPVA for paroxysmal AF. Methods and Results-Data were collected on 297 patients undergoing CPVA for paroxysmal AF. Abolition of all evoked vagal reflexes around all pulmonary vein ostia was defined as complete vagal denervation (CVD) and was obtained in 34.3% of patients. Follow-up ended at 12 months. Heart rate variability attenuation, consistent with vagal withdrawal, was detectable for up to 3 months after CPVA, particularly in patients with reflexes and CVD, who were less likely to have recurrent AF than those without reflexes (P=0.0002, log-rank test). Only the percentage area of left atrial isolation and CVD were predictors of AF recurrence after CPVA (P

Original languageEnglish
Pages (from-to)327-334
Number of pages8
JournalCirculation
Volume109
Issue number3
DOIs
Publication statusPublished - Jan 27 2004

Keywords

  • Ablation
  • Arrhythmia
  • Atrium
  • Fibrillation
  • Nervous system, autonomic

ASJC Scopus subject areas

  • Physiology
  • Cardiology and Cardiovascular Medicine

Fingerprint Dive into the research topics of 'Pulmonary Vein Denervation Enhances Long-Term Benefit after Circumferential Ablation for Paroxysmal Atrial Fibrillation'. Together they form a unique fingerprint.

  • Cite this