Pulmonary vein isolation after circumferential pulmonary vein ablation: Comparison between Lasso and three-dimensional electroanatomical assessment of complete electrical disconnection

Background: Pulmonary vein isolation (PVI) is one of the common endpoints of all atrial fibrillation (AF) ablation procedures and is most often validated using a preshaped circular catheter. However, three-dimensional (3D) electroanatomical systems used for anatomy reconstruction and to guide coalescent delivery of ablation lesions avoid the use of multiple transeptal punctures and multiple catheters in the left atrium. Objective: To assess correspondence in PVI validation between a 3D electroanatomical system and a Lasso catheter. Methods: Twenty-five patients affected by nonpermanent AF were enrolled after giving informed consent. After ablation of all four pulmonary vein (PV) ostia, encircled areas were extensively mapped (15 ± 5 points acquired for each PV ostium) to assess the absence of any electrical activity conducted from the left atrium to the PV. At the end of the procedure, the physician performing the ablation procedure judged the complete versus incomplete PVI according to Carto/ablation catheter mapping during coronary sinus pacing. Thereafter, a second operator blinded to the result of the ablation procedure positioned a preshaped Lasso catheter in each PV ostium and annotated complete/incomplete PVI during pacing from the coronary sinus. Results: PVI as assessed with CARTO was 100% concordant with Lasso evaluation of PVI. Fluoroscopic times were 2.5 ± 0.9 minutes to complete circumferential PV ablation and 5.5 ± 1.9 minutes to properly position the Lasso catheter. No acute complications were reported in this series of patients. Conclusions: PVI assessment using a 3D electroanatomical system is as accurate as Lasso evaluation, with excellent concordance.