Pulsatile stretch induces release of angiotensin II and oxidative stress in human endothelial cells: Effects of ACE inhibition and AT1 receptor antagonism

Chiara Delli Gatti, Elena Osto, Alexei Kouroedov, Masato Eto, Sidney Shaw, Massimo Volpe, Thomas F. Luscher, Francesco Cosentino

Research output: Contribution to journalArticlepeer-review

Abstract

Mechanical forces and the activation of the renin-angiotensin system (RAS) may alter the NO/O2 •- balance, imparing endothelial nitric oxide (NO) availability. This study investigates the link between RAS and NO/O2 •- balance in human aortic endothelial cells (HAEC) exposed to pulsatile stretch with and without ACE inhibitor quinaprilat or angiotensin II type 1 (AT1) receptor antagonist losartan. Pulsatile stretch increased Ang II levels and O2 •- production, reducing NO release. RAS blockade with quinaprilat or losartan restored the balance between NO and O2 •-. These results provide a molecular basis for understanding the vascular protective effects of ACE inhibition and AT1 receptor antagonism.

Original languageEnglish
Pages (from-to)616-627
Number of pages12
JournalClinical and Experimental Hypertension
Volume30
Issue number7
DOIs
Publication statusPublished - Oct 2008

Keywords

  • Endothelium
  • Free radicals
  • Nitric oxide
  • Renin angiotensin system

ASJC Scopus subject areas

  • Internal Medicine
  • Physiology

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