Pulse wave velocity distribution in a cohort study: Fromarterial stiffness to early vascular aging

Pedro G. Cunha, Jorge Cotter, Pedro Oliveira, Isabel Vila, Pierre Boutouyrie, Stéphane Laurent, Peter M. Nilsson, Angelo Scuteri, Nuno Sousa

Research output: Contribution to journalArticlepeer-review


Background: By contrast with other southern European people, north Portuguese population registers an especially high prevalence of hypertension and stroke incidence. We designed a cohort study to identify individuals presenting accelerated and premature arterial aging in the Portuguese population. Method: Pulse wave velocity (PWV) was measured in randomly sampled population dwellers aged 18-96 years from northern Portugal, and used as a marker of early vascular aging (EVA). Of the 3038 individuals enrolled, 2542 completed the evaluation. Results: Mean PWV value for the entire population was 8.4 m/s (men: 8.6 m/s; women: 8.2 m/s; P10 m/s). Logistic regression models indicated gender differences concerning the risk of developing large artery damage, with women having the same odds of PWV above 10 m/s 10 years later than men. Conclusion: The population PWV values were higher than expected in a low cardiovascular risk area (Portugal). High prevalence rates of EVA and noteworthy large artery damage in young ages were found.

Original languageEnglish
Pages (from-to)1438-1445
Number of pages8
JournalJournal of Hypertension
Issue number7
Publication statusPublished - 2015


  • Arterial stiffness
  • Cardiovascular risk
  • Early vascular aging
  • Epidemiology
  • Large artery
  • Portugal
  • Pulse wave velocity

ASJC Scopus subject areas

  • Internal Medicine
  • Physiology
  • Cardiology and Cardiovascular Medicine


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