Pulsed dose-rate perioperative interstitial brachytherapy for soft tissue sarcomas of the extremities and skeletal muscles of the trunk

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15 Citations (Scopus)

Abstract

Background: This study evaluated the role of pulsed dose-rate (PDR) brachytherapy (BRT), delivered alone or as a boost to external beam radiotherapy, as adjuvant therapy for the local control of soft tissue sarcomas of the extremities and skeletal muscles of the trunk that have undergone surgical treatment. Methods: Between July 1998 and January 2002, 42 patients were treated with a combination of surgery and BRT alone (18 patients) or BRT/external beam radiotherapy (24 patients) for the treatment of primary (n = 32) and recurrent (n = 10) soft tissue sarcomas located in the proximal extremity (n = 17), distal extremity (n = 17), and trunk (n = 8). Tumor size was 5 cm in 22 cases, with histological grading of 1 (n = 7), 2 (n = 18), or 3 (n = 17). The median BRT dose delivered was 15 Gy, and the median external beam irradiation dose was 50 Gy. Results: With a median follow-up of 34 months, the 36-month survival was 83.9% (SE, 6.1%), and the local control was 89%. Conclusions: PDR interstitial BRT for soft tissue sarcoma is an effective, well-tolerated adjuvant radiation treatment that offers several practical advantages, among which are low acute and late toxicity with maximum normal tissue and critical structure sparing and overall shorter radiotherapy and hospital stay.

Original languageEnglish
Pages (from-to)935-942
Number of pages8
JournalAnnals of Surgical Oncology
Volume12
Issue number11
DOIs
Publication statusPublished - Nov 2005

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Brachytherapy
Sarcoma
Skeletal Muscle
Extremities
Radiotherapy
Adjuvant Radiotherapy
Therapeutics
Length of Stay
Radiation
Survival
Neoplasms

Keywords

  • Adjuvant therapy
  • Pulsed dose-rate brachytherapy
  • Radiotherapy
  • Soft tissue sarcoma

ASJC Scopus subject areas

  • Surgery
  • Oncology

Cite this

@article{4dd593e101404e809332c22cb32fec1b,
title = "Pulsed dose-rate perioperative interstitial brachytherapy for soft tissue sarcomas of the extremities and skeletal muscles of the trunk",
abstract = "Background: This study evaluated the role of pulsed dose-rate (PDR) brachytherapy (BRT), delivered alone or as a boost to external beam radiotherapy, as adjuvant therapy for the local control of soft tissue sarcomas of the extremities and skeletal muscles of the trunk that have undergone surgical treatment. Methods: Between July 1998 and January 2002, 42 patients were treated with a combination of surgery and BRT alone (18 patients) or BRT/external beam radiotherapy (24 patients) for the treatment of primary (n = 32) and recurrent (n = 10) soft tissue sarcomas located in the proximal extremity (n = 17), distal extremity (n = 17), and trunk (n = 8). Tumor size was 5 cm in 22 cases, with histological grading of 1 (n = 7), 2 (n = 18), or 3 (n = 17). The median BRT dose delivered was 15 Gy, and the median external beam irradiation dose was 50 Gy. Results: With a median follow-up of 34 months, the 36-month survival was 83.9{\%} (SE, 6.1{\%}), and the local control was 89{\%}. Conclusions: PDR interstitial BRT for soft tissue sarcoma is an effective, well-tolerated adjuvant radiation treatment that offers several practical advantages, among which are low acute and late toxicity with maximum normal tissue and critical structure sparing and overall shorter radiotherapy and hospital stay.",
keywords = "Adjuvant therapy, Pulsed dose-rate brachytherapy, Radiotherapy, Soft tissue sarcoma",
author = "Gianluca Lazzaro and Roberta Lazzari and Giuseppe Pelosi and {De Pas}, Tommaso and Luigi Mariani and Giovanni Mazzarol and Daniele Sances and Giulio Tosti and Federica Baldini and Massimo Mosconi and Ines Tedeschi and Giuseppe Viale and Hugo Marsiglia and Antonio Chiappa and Andrea Vavassori and Roberto Orecchia and Alessandro Testori",
year = "2005",
month = "11",
doi = "10.1245/ASO.2005.11.004",
language = "English",
volume = "12",
pages = "935--942",
journal = "Annals of Surgical Oncology",
issn = "1068-9265",
publisher = "Springer New York LLC",
number = "11",

}

TY - JOUR

T1 - Pulsed dose-rate perioperative interstitial brachytherapy for soft tissue sarcomas of the extremities and skeletal muscles of the trunk

AU - Lazzaro, Gianluca

AU - Lazzari, Roberta

AU - Pelosi, Giuseppe

AU - De Pas, Tommaso

AU - Mariani, Luigi

AU - Mazzarol, Giovanni

AU - Sances, Daniele

AU - Tosti, Giulio

AU - Baldini, Federica

AU - Mosconi, Massimo

AU - Tedeschi, Ines

AU - Viale, Giuseppe

AU - Marsiglia, Hugo

AU - Chiappa, Antonio

AU - Vavassori, Andrea

AU - Orecchia, Roberto

AU - Testori, Alessandro

PY - 2005/11

Y1 - 2005/11

N2 - Background: This study evaluated the role of pulsed dose-rate (PDR) brachytherapy (BRT), delivered alone or as a boost to external beam radiotherapy, as adjuvant therapy for the local control of soft tissue sarcomas of the extremities and skeletal muscles of the trunk that have undergone surgical treatment. Methods: Between July 1998 and January 2002, 42 patients were treated with a combination of surgery and BRT alone (18 patients) or BRT/external beam radiotherapy (24 patients) for the treatment of primary (n = 32) and recurrent (n = 10) soft tissue sarcomas located in the proximal extremity (n = 17), distal extremity (n = 17), and trunk (n = 8). Tumor size was 5 cm in 22 cases, with histological grading of 1 (n = 7), 2 (n = 18), or 3 (n = 17). The median BRT dose delivered was 15 Gy, and the median external beam irradiation dose was 50 Gy. Results: With a median follow-up of 34 months, the 36-month survival was 83.9% (SE, 6.1%), and the local control was 89%. Conclusions: PDR interstitial BRT for soft tissue sarcoma is an effective, well-tolerated adjuvant radiation treatment that offers several practical advantages, among which are low acute and late toxicity with maximum normal tissue and critical structure sparing and overall shorter radiotherapy and hospital stay.

AB - Background: This study evaluated the role of pulsed dose-rate (PDR) brachytherapy (BRT), delivered alone or as a boost to external beam radiotherapy, as adjuvant therapy for the local control of soft tissue sarcomas of the extremities and skeletal muscles of the trunk that have undergone surgical treatment. Methods: Between July 1998 and January 2002, 42 patients were treated with a combination of surgery and BRT alone (18 patients) or BRT/external beam radiotherapy (24 patients) for the treatment of primary (n = 32) and recurrent (n = 10) soft tissue sarcomas located in the proximal extremity (n = 17), distal extremity (n = 17), and trunk (n = 8). Tumor size was 5 cm in 22 cases, with histological grading of 1 (n = 7), 2 (n = 18), or 3 (n = 17). The median BRT dose delivered was 15 Gy, and the median external beam irradiation dose was 50 Gy. Results: With a median follow-up of 34 months, the 36-month survival was 83.9% (SE, 6.1%), and the local control was 89%. Conclusions: PDR interstitial BRT for soft tissue sarcoma is an effective, well-tolerated adjuvant radiation treatment that offers several practical advantages, among which are low acute and late toxicity with maximum normal tissue and critical structure sparing and overall shorter radiotherapy and hospital stay.

KW - Adjuvant therapy

KW - Pulsed dose-rate brachytherapy

KW - Radiotherapy

KW - Soft tissue sarcoma

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U2 - 10.1245/ASO.2005.11.004

DO - 10.1245/ASO.2005.11.004

M3 - Article

VL - 12

SP - 935

EP - 942

JO - Annals of Surgical Oncology

JF - Annals of Surgical Oncology

SN - 1068-9265

IS - 11

ER -