Abstract
Background: This study evaluated the role of pulsed dose-rate (PDR) brachytherapy (BRT), delivered alone or as a boost to external beam radiotherapy, as adjuvant therapy for the local control of soft tissue sarcomas of the extremities and skeletal muscles of the trunk that have undergone surgical treatment. Methods: Between July 1998 and January 2002, 42 patients were treated with a combination of surgery and BRT alone (18 patients) or BRT/external beam radiotherapy (24 patients) for the treatment of primary (n = 32) and recurrent (n = 10) soft tissue sarcomas located in the proximal extremity (n = 17), distal extremity (n = 17), and trunk (n = 8). Tumor size was 5 cm in 22 cases, with histological grading of 1 (n = 7), 2 (n = 18), or 3 (n = 17). The median BRT dose delivered was 15 Gy, and the median external beam irradiation dose was 50 Gy. Results: With a median follow-up of 34 months, the 36-month survival was 83.9% (SE, 6.1%), and the local control was 89%. Conclusions: PDR interstitial BRT for soft tissue sarcoma is an effective, well-tolerated adjuvant radiation treatment that offers several practical advantages, among which are low acute and late toxicity with maximum normal tissue and critical structure sparing and overall shorter radiotherapy and hospital stay.
| Original language | English |
|---|---|
| Pages (from-to) | 935-942 |
| Number of pages | 8 |
| Journal | Annals of Surgical Oncology |
| Volume | 12 |
| Issue number | 11 |
| DOIs | |
| Publication status | Published - Nov 2005 |
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Keywords
- Adjuvant therapy
- Pulsed dose-rate brachytherapy
- Radiotherapy
- Soft tissue sarcoma
ASJC Scopus subject areas
- Surgery
- Oncology
Cite this
Pulsed dose-rate perioperative interstitial brachytherapy for soft tissue sarcomas of the extremities and skeletal muscles of the trunk. / Lazzaro, Gianluca; Lazzari, Roberta; Pelosi, Giuseppe; De Pas, Tommaso; Mariani, Luigi; Mazzarol, Giovanni; Sances, Daniele; Tosti, Giulio; Baldini, Federica; Mosconi, Massimo; Tedeschi, Ines; Viale, Giuseppe; Marsiglia, Hugo; Chiappa, Antonio; Vavassori, Andrea; Orecchia, Roberto; Testori, Alessandro.
In: Annals of Surgical Oncology, Vol. 12, No. 11, 11.2005, p. 935-942.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Pulsed dose-rate perioperative interstitial brachytherapy for soft tissue sarcomas of the extremities and skeletal muscles of the trunk
AU - Lazzaro, Gianluca
AU - Lazzari, Roberta
AU - Pelosi, Giuseppe
AU - De Pas, Tommaso
AU - Mariani, Luigi
AU - Mazzarol, Giovanni
AU - Sances, Daniele
AU - Tosti, Giulio
AU - Baldini, Federica
AU - Mosconi, Massimo
AU - Tedeschi, Ines
AU - Viale, Giuseppe
AU - Marsiglia, Hugo
AU - Chiappa, Antonio
AU - Vavassori, Andrea
AU - Orecchia, Roberto
AU - Testori, Alessandro
PY - 2005/11
Y1 - 2005/11
N2 - Background: This study evaluated the role of pulsed dose-rate (PDR) brachytherapy (BRT), delivered alone or as a boost to external beam radiotherapy, as adjuvant therapy for the local control of soft tissue sarcomas of the extremities and skeletal muscles of the trunk that have undergone surgical treatment. Methods: Between July 1998 and January 2002, 42 patients were treated with a combination of surgery and BRT alone (18 patients) or BRT/external beam radiotherapy (24 patients) for the treatment of primary (n = 32) and recurrent (n = 10) soft tissue sarcomas located in the proximal extremity (n = 17), distal extremity (n = 17), and trunk (n = 8). Tumor size was 5 cm in 22 cases, with histological grading of 1 (n = 7), 2 (n = 18), or 3 (n = 17). The median BRT dose delivered was 15 Gy, and the median external beam irradiation dose was 50 Gy. Results: With a median follow-up of 34 months, the 36-month survival was 83.9% (SE, 6.1%), and the local control was 89%. Conclusions: PDR interstitial BRT for soft tissue sarcoma is an effective, well-tolerated adjuvant radiation treatment that offers several practical advantages, among which are low acute and late toxicity with maximum normal tissue and critical structure sparing and overall shorter radiotherapy and hospital stay.
AB - Background: This study evaluated the role of pulsed dose-rate (PDR) brachytherapy (BRT), delivered alone or as a boost to external beam radiotherapy, as adjuvant therapy for the local control of soft tissue sarcomas of the extremities and skeletal muscles of the trunk that have undergone surgical treatment. Methods: Between July 1998 and January 2002, 42 patients were treated with a combination of surgery and BRT alone (18 patients) or BRT/external beam radiotherapy (24 patients) for the treatment of primary (n = 32) and recurrent (n = 10) soft tissue sarcomas located in the proximal extremity (n = 17), distal extremity (n = 17), and trunk (n = 8). Tumor size was 5 cm in 22 cases, with histological grading of 1 (n = 7), 2 (n = 18), or 3 (n = 17). The median BRT dose delivered was 15 Gy, and the median external beam irradiation dose was 50 Gy. Results: With a median follow-up of 34 months, the 36-month survival was 83.9% (SE, 6.1%), and the local control was 89%. Conclusions: PDR interstitial BRT for soft tissue sarcoma is an effective, well-tolerated adjuvant radiation treatment that offers several practical advantages, among which are low acute and late toxicity with maximum normal tissue and critical structure sparing and overall shorter radiotherapy and hospital stay.
KW - Adjuvant therapy
KW - Pulsed dose-rate brachytherapy
KW - Radiotherapy
KW - Soft tissue sarcoma
UR - http://www.scopus.com/inward/record.url?scp=27144544046&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=27144544046&partnerID=8YFLogxK
U2 - 10.1245/ASO.2005.11.004
DO - 10.1245/ASO.2005.11.004
M3 - Article
VL - 12
SP - 935
EP - 942
JO - Annals of Surgical Oncology
JF - Annals of Surgical Oncology
SN - 1068-9265
IS - 11
ER -