Pulsed electromagnetic field with Temozolomide can elicit an epigenetic pro-Apoptotic effect on Glioblastoma T98G Cells

Francesca Pasi, Lorenzo Fassina, Maria Evelina Mognaschi, Giuseppe Lupo, Franco Corbella, Rosanna Nano, Enrica Capelli

Research output: Contribution to journalArticlepeer-review

Abstract

Treatment with pulsed electromagnetic fields (PEMFs) is emerging as an interesting therapeutic option for patients with cancer. The literature has demonstrated that low-frequency/low-energy electromagnetic fields do not cause predictable effects on DNA; however, they can epigenetically act on gene expression. The aim of the present work was to study a possible epigenetic effect of a PEMF, mediated by miRNAs, on a human glioblastoma cell line (T98G). We tested a PEMF (maximum magnetic induction, 2 mT; frequency, 75 Hz) that has been demonstrated to induce autophagy in glioblastoma cells. In particular, we studied the effect of PEMF on the expression of genes involved in cancer progression and a promising synergistic effect with temozolomide, a frequently used drug to treat glioblastoma multiforme. We found that electromagnetic stimulation in combination with temozolomide can elicit an epigenetic pro-Apoptotic effect in the chemo-and radioresistant T98G glioblastoma cell line.

Original languageEnglish
Pages (from-to)5821-5826
Number of pages6
JournalAnticancer Research
Volume36
Issue number11
DOIs
Publication statusPublished - Nov 1 2016

Keywords

  • Epigenetic Pro-Apoptotic Effect
  • Glioblastoma Multiforme
  • Pulsed Electromagnetic Stimulation
  • Temozolomide

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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