TY - JOUR
T1 - Pulsed electromagnetic field with Temozolomide can elicit an epigenetic pro-Apoptotic effect on Glioblastoma T98G Cells
AU - Pasi, Francesca
AU - Fassina, Lorenzo
AU - Mognaschi, Maria Evelina
AU - Lupo, Giuseppe
AU - Corbella, Franco
AU - Nano, Rosanna
AU - Capelli, Enrica
PY - 2016/11/1
Y1 - 2016/11/1
N2 - Treatment with pulsed electromagnetic fields (PEMFs) is emerging as an interesting therapeutic option for patients with cancer. The literature has demonstrated that low-frequency/low-energy electromagnetic fields do not cause predictable effects on DNA; however, they can epigenetically act on gene expression. The aim of the present work was to study a possible epigenetic effect of a PEMF, mediated by miRNAs, on a human glioblastoma cell line (T98G). We tested a PEMF (maximum magnetic induction, 2 mT; frequency, 75 Hz) that has been demonstrated to induce autophagy in glioblastoma cells. In particular, we studied the effect of PEMF on the expression of genes involved in cancer progression and a promising synergistic effect with temozolomide, a frequently used drug to treat glioblastoma multiforme. We found that electromagnetic stimulation in combination with temozolomide can elicit an epigenetic pro-Apoptotic effect in the chemo-and radioresistant T98G glioblastoma cell line.
AB - Treatment with pulsed electromagnetic fields (PEMFs) is emerging as an interesting therapeutic option for patients with cancer. The literature has demonstrated that low-frequency/low-energy electromagnetic fields do not cause predictable effects on DNA; however, they can epigenetically act on gene expression. The aim of the present work was to study a possible epigenetic effect of a PEMF, mediated by miRNAs, on a human glioblastoma cell line (T98G). We tested a PEMF (maximum magnetic induction, 2 mT; frequency, 75 Hz) that has been demonstrated to induce autophagy in glioblastoma cells. In particular, we studied the effect of PEMF on the expression of genes involved in cancer progression and a promising synergistic effect with temozolomide, a frequently used drug to treat glioblastoma multiforme. We found that electromagnetic stimulation in combination with temozolomide can elicit an epigenetic pro-Apoptotic effect in the chemo-and radioresistant T98G glioblastoma cell line.
KW - Epigenetic Pro-Apoptotic Effect
KW - Glioblastoma Multiforme
KW - Pulsed Electromagnetic Stimulation
KW - Temozolomide
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U2 - 10.21873/anticanres.11166
DO - 10.21873/anticanres.11166
M3 - Article
AN - SCOPUS:84994005317
VL - 36
SP - 5821
EP - 5826
JO - Anticancer Research
JF - Anticancer Research
SN - 0250-7005
IS - 11
ER -