Pupillary and cardiovascular responses to the cold-pressor test

Cristina Tassorelli, Giuseppe Micieli, Vera Osipova, Francesco Rossi, Giuseppe Nappi

Research output: Contribution to journalArticle

43 Citations (Scopus)

Abstract

Little is known about the structures and mechanisms involved in the autonomic response to sensory and nociceptive stimulation. In this study, we recorded simultaneously pupil diameter, blood pressure, heart rate and pain levels during a cold-pressor test in 10 healthy subjects. The aim was to evaluate the different components of the Autonomic Nervous System involved in the response to a thermal-painful stimulus. A biphasic pupillary response was observed: an initial, short-lasting mydriasis, followed by a miotic phase, this latter characterized by rhythmic fluctuations of pupil diameter. The blood pressure response was monophasic with a moderate increase observed from the second minute of the test. Pain intensities remained stable on medium-high levels throughout the test. The topical application of thymoxamine and homatropine clarified some aspects of the pupillary response. The systemic administration of naloxone suggested a role of opiates in the modulation of pupillary and cardiovascular response to the cold-pressor test.

Original languageEnglish
Pages (from-to)45-49
Number of pages5
JournalJournal of the Autonomic Nervous System
Volume55
Issue number1-2
DOIs
Publication statusPublished - Oct 5 1995

Fingerprint

Pupil
Opiate Alkaloids
Moxisylyte
Miotics
Blood Pressure
Mydriasis
Pain
Autonomic Nervous System
Naloxone
Healthy Volunteers
Hot Temperature
Heart Rate
homatropine

Keywords

  • Cardiovascular response
  • Opiate
  • Pain
  • Pupil

ASJC Scopus subject areas

  • Physiology
  • Clinical Neurology
  • Neuroscience(all)

Cite this

Pupillary and cardiovascular responses to the cold-pressor test. / Tassorelli, Cristina; Micieli, Giuseppe; Osipova, Vera; Rossi, Francesco; Nappi, Giuseppe.

In: Journal of the Autonomic Nervous System, Vol. 55, No. 1-2, 05.10.1995, p. 45-49.

Research output: Contribution to journalArticle

Tassorelli, Cristina ; Micieli, Giuseppe ; Osipova, Vera ; Rossi, Francesco ; Nappi, Giuseppe. / Pupillary and cardiovascular responses to the cold-pressor test. In: Journal of the Autonomic Nervous System. 1995 ; Vol. 55, No. 1-2. pp. 45-49.
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