Pupillometric evaluation and analysis of light reflex in healthy subjects as a tool to study autonomic nervous system changes with aging

G. Pozzessere, E. Valle, P. Rossi, B. Petrucci, A. Ambrosini, M. D'Alessio, F. Pierelli, P. Giacomini

Research output: Contribution to journalArticle

Abstract

To assess the relationships between aging and autonomic control of pupillary functions, TV-pupillometry and light reflex evaluation were performed in 52 healthy volunteers in the age range 15-75 years, grouped into four age classes (group 1: 15-29 years, Group 2: 30-44 years, Group 3: 45-59 years, Group 4: 60-75 years). Baseline light pupil diameter was found to be age-dependent, together with light reflex contraction velocity, which presented a linear correlation with age. Light reflex amplitude and half-redilatation velocity were reduced in older subjects, but presented only a weak linear correlation with age, while latency, contraction time and half-redilatation time percent of secondary dilatation and redilatation at 5 seconds did not show significant changes with age. These results confirm that there are important age-dependent changes in the mechanisms involved in pupillary autonomic functions, regarding both sympathetic and parasympathetic components. These changes appear to be easily detectable by making use of a sensitive and non-invasive technique such as TV-pupillometry.

Original languageEnglish
Pages (from-to)55-60
Number of pages6
JournalAging clinical and experimental research
Volume8
Issue number1
Publication statusPublished - Feb 1996

Keywords

  • Aging
  • Autonomic nervous system
  • Infrared videopupillometry
  • Pupillary light reflex

ASJC Scopus subject areas

  • Ageing
  • Geriatrics and Gerontology

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