Pupillometry and radioreceptor binding. Semeiologic suggestions in the evaluation of the treatment with anticholinergic drugs

Research output: Contribution to journalArticle

Abstract

In this study, a dynamic TV pupillometric system has been used to record the effects of the anticholinergic drug biperidene (Akineton®) on pupil responsiveness to various types of stimuli. Plasma levels of the drug were evaluated by means of the radioreceptor binding technique at the same times of pupillometric monitoring. An excellent correlation was found between the effects of biperidene on pupil diameter after light and dark adaptation, light reflex and near vision reaction and the plasma levels of the drug. Radioreceptor binding and dynamic TV pupillometry represent useful tools to evaluate the possible alterations induced by drug therapy on the cholinergic system in man.

Original languageEnglish
Pages (from-to)647-650
Number of pages4
JournalArzneimittel-Forschung/Drug Research
Volume40
Issue number6
Publication statusPublished - 1990

Keywords

  • Akineton®
  • anticholinergic drugs
  • antiparkinson drugs
  • biperidene, clinical studies
  • pupillometry
  • radioreceptor binding

ASJC Scopus subject areas

  • Chemistry(all)
  • Organic Chemistry
  • Drug Discovery
  • Pharmacology

Fingerprint Dive into the research topics of 'Pupillometry and radioreceptor binding. Semeiologic suggestions in the evaluation of the treatment with anticholinergic drugs'. Together they form a unique fingerprint.

  • Cite this