Pure autonomic failure with cold induced sweating

Juan Idiaquez, Ricardo Fadic, Renato Verdugo, Juan F. Idiaquez, Valeria Iodice, David A. Low, C. J. Mathias, Raffaela Lombardi, Giuseppe Lauria

Research output: Contribution to journalArticle

Abstract

Pure autonomic failure (PAF) is a progressive autonomic neurodegenerative disorder. Cold induced sweating occurred in syndromes with mutations in CRLF1 and CLCF1 genes and in a case of cervical dissection.A patient with PAF developed sweating induced by cool ambient temperatures. He had severe orthostatic hypotension, abnormal cardiovagal reflexes, and paradoxical sweating in the upper trunk at a room temperature of 18. °C. Skin biopsy showed involvement of somatic epidermal unmyelinated nerve fibers. Quantitative sensory testing showed abnormal thresholds to all thermal modalities. Possible mechanisms include cold induced noradrenaline release in remaining autonomic innervation and a supersensitive sudomotor response.

Original languageEnglish
Pages (from-to)98-100
Number of pages3
JournalAutonomic Neuroscience: Basic and Clinical
Volume176
Issue number1-2
DOIs
Publication statusPublished - Jun 2013

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Keywords

  • Autonomic
  • Cold sweating
  • Failure
  • Pure

ASJC Scopus subject areas

  • Clinical Neurology
  • Cellular and Molecular Neuroscience
  • Endocrine and Autonomic Systems

Cite this

Idiaquez, J., Fadic, R., Verdugo, R., Idiaquez, J. F., Iodice, V., Low, D. A., Mathias, C. J., Lombardi, R., & Lauria, G. (2013). Pure autonomic failure with cold induced sweating. Autonomic Neuroscience: Basic and Clinical, 176(1-2), 98-100. https://doi.org/10.1016/j.autneu.2013.02.019