Of 120 patients with malformations of cortical development diagnosed on MRI at our centers (Dept of Neurological Sciences and Bellaria Hospital, Bologna), we studied 15 patients with Periventricular Nodular Heterotopia. Patients with only periventricular nodules ("Pure") showed seizures with onset in the second decade, usually rare and partial secondarily generalised, and drug responsive. EEG disclosed focal abnormalities. Patients with additional malformations ("Plus") had a male preponderance, usually showed mental retardation associated with seizure with high frequency, early and drug resistance; sudden drops were observed in 5 patients. EEG showed focal and bisynchronous abnormalities. We conclude that the evidence of other types of cortical or cerebral malformation, in addition to periventricular nodules, determines a worse prognosis.
|Translated title of the contribution||"Pure" periventricular nodular heterotopia vs periventricular nodular heterotopia "plus": Electroclinical and prognostic differences|
|Number of pages||3|
|Journal||Bollettino - Lega Italiana contro l'Epilessia|
|Publication status||Published - Oct 2002|
ASJC Scopus subject areas
- Clinical Neurology