Pure uptake blockers of dopamine can reduce prolactin secretion: Studies with diclofensine

Gianfranco Di Renzo, Salvatore Amoroso, Maurizio Taglialatela, Lorella M T Canzoniero, Paola Maida, Gaetano Lombardi, Lucio Annunziato

Research output: Contribution to journalArticle

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Abstract

The effects of diclofensine, a pure dopamine (DA) uptake inhibitor on 1) 3H-DA uptake in rat arcuate-periventricular nucleus-median eminence synaptosomes, 2) basal and K+-evoked endogenous DA release from tuberoinfundibular dopaminergic (TIDA) neurons and 3) in vivo prolactin (PRL) secretion were studied. Diclofensine, in concentrations of 0.01, 0.1 and 1 μM caused a marked decrease of 3H-DA uptake. In addition, it was unable to stimulate basal endogenous DA release which, on the contrary, was elicited by d-amphetamine in the same concentration (50 μM). On the other hand, diclofensine (50 μM) caused a 3 fold enhancement of K+-evoked DA release. Finally, the compound, when administered in vivo to male rats, significantly reduced basal serum PRL levels. The results of the present study seem to indicate that the pharmacological blockade of DA uptake in TIDA neurons is a condition sufficient to cause a reduction of PRL release.

Original languageEnglish
Pages (from-to)2161-2169
Number of pages9
JournalLife Sciences
Volume42
Issue number21
DOIs
Publication statusPublished - 1988

Fingerprint

Dopamine Antagonists
Prolactin
Dopamine
Dopaminergic Neurons
Neurons
Rats
Dopamine Uptake Inhibitors
Dextroamphetamine
Median Eminence
Arcuate Nucleus of Hypothalamus
Synaptosomes
diclofensine
Pharmacology
Serum

ASJC Scopus subject areas

  • Pharmacology

Cite this

Di Renzo, G., Amoroso, S., Taglialatela, M., Canzoniero, L. M. T., Maida, P., Lombardi, G., & Annunziato, L. (1988). Pure uptake blockers of dopamine can reduce prolactin secretion: Studies with diclofensine. Life Sciences, 42(21), 2161-2169. https://doi.org/10.1016/0024-3205(88)90131-2

Pure uptake blockers of dopamine can reduce prolactin secretion : Studies with diclofensine. / Di Renzo, Gianfranco; Amoroso, Salvatore; Taglialatela, Maurizio; Canzoniero, Lorella M T; Maida, Paola; Lombardi, Gaetano; Annunziato, Lucio.

In: Life Sciences, Vol. 42, No. 21, 1988, p. 2161-2169.

Research output: Contribution to journalArticle

Di Renzo, G, Amoroso, S, Taglialatela, M, Canzoniero, LMT, Maida, P, Lombardi, G & Annunziato, L 1988, 'Pure uptake blockers of dopamine can reduce prolactin secretion: Studies with diclofensine', Life Sciences, vol. 42, no. 21, pp. 2161-2169. https://doi.org/10.1016/0024-3205(88)90131-2
Di Renzo G, Amoroso S, Taglialatela M, Canzoniero LMT, Maida P, Lombardi G et al. Pure uptake blockers of dopamine can reduce prolactin secretion: Studies with diclofensine. Life Sciences. 1988;42(21):2161-2169. https://doi.org/10.1016/0024-3205(88)90131-2
Di Renzo, Gianfranco ; Amoroso, Salvatore ; Taglialatela, Maurizio ; Canzoniero, Lorella M T ; Maida, Paola ; Lombardi, Gaetano ; Annunziato, Lucio. / Pure uptake blockers of dopamine can reduce prolactin secretion : Studies with diclofensine. In: Life Sciences. 1988 ; Vol. 42, No. 21. pp. 2161-2169.
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