Purification and partial characterization of a daunorubicin-binding protein from rat liver

R. A. Gambetta, A. Colombo, C. Lanzi, F. Zunino

Research output: Contribution to journalArticle


A daunorubicin-binding protein has been isolated from the soluble fraction of normal rat liver by affinity chromatography on daunorubicin-Sepharose columns. This protein, which apparently binds anthracyclines specifically, appears to be composed of four polypeptides of 54,000 M(r), is different from tubulin, and is not involved in anthracycline metabolism. Its physiological function remains to be determined.

Original languageEnglish
Pages (from-to)336-340
Number of pages5
JournalMolecular Pharmacology
Issue number2
Publication statusPublished - 1983


ASJC Scopus subject areas

  • Pharmacology

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