TY - JOUR
T1 - Purification by ozonolysis of 18O enriched water after cyclotron irradiation and the utilization of the purified water for the production of [18F]-FDG (2-deoxy-2-[18F]-fluoro-d-glucose)
AU - Asti, M.
AU - Grassi, E.
AU - Sghedoni, R.
AU - De Pietri, G.
AU - Fioroni, F.
AU - Versari, A.
AU - Borasi, G.
AU - Salvo, D.
PY - 2007/7
Y1 - 2007/7
N2 - The high cost of virgin 18O-enriched water has forced many researchers to study methods to purify and recycle enriched water after the first irradiation for the production of radiopharmaceuticals. In our study, [18O]H2O was purified by ozonolysis and distillation. Analyses showed a large decrease in impurities after this treatment. The purification procedure was carried out after the production of 94 batches of [18F]-FDG, which were manufactured using a GE Minitrace cyclotron and a GE Mx TracerLab synthesizer. Saturation yields after bombardment, using virgin and re-purified water were, respectively, 2864±204 MBq/μA and 2727±167 MBq/μA, a decrease of 5.5%. The decrease in [18F]-FDG yield, from 67.2±0.7% to 65.5±0.9%, can be ascribed to the irradiation step only.
AB - The high cost of virgin 18O-enriched water has forced many researchers to study methods to purify and recycle enriched water after the first irradiation for the production of radiopharmaceuticals. In our study, [18O]H2O was purified by ozonolysis and distillation. Analyses showed a large decrease in impurities after this treatment. The purification procedure was carried out after the production of 94 batches of [18F]-FDG, which were manufactured using a GE Minitrace cyclotron and a GE Mx TracerLab synthesizer. Saturation yields after bombardment, using virgin and re-purified water were, respectively, 2864±204 MBq/μA and 2727±167 MBq/μA, a decrease of 5.5%. The decrease in [18F]-FDG yield, from 67.2±0.7% to 65.5±0.9%, can be ascribed to the irradiation step only.
KW - [F]-FDG
KW - [O]HO
KW - Cyclotron
KW - Enriched water
KW - Radiopharmaceuticals
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U2 - 10.1016/j.apradiso.2007.03.003
DO - 10.1016/j.apradiso.2007.03.003
M3 - Article
C2 - 17459713
AN - SCOPUS:34248219998
VL - 65
SP - 831
EP - 835
JO - Applied Radiation and Isotopes
JF - Applied Radiation and Isotopes
SN - 0969-8043
IS - 7
ER -