Purification by ozonolysis of 18O enriched water after cyclotron irradiation and the utilization of the purified water for the production of [18F]-FDG (2-deoxy-2-[18F]-fluoro-d-glucose)

M. Asti; E. Grassi; R. Sghedoni; G. De Pietri; F. Fioroni; A. Versari; G. Borasi; D. Salvo

doi:10.1016/j.apradiso.2007.03.003

Purification by ozonolysis of 18O enriched water after cyclotron irradiation and the utilization of the purified water for the production of [18F]-FDG (2-deoxy-2-[18F]-fluoro-d-glucose)

M. Asti, E. Grassi, R. Sghedoni, G. De Pietri, F. Fioroni, A. Versari, G. Borasi, D. Salvo

Arcispedale Santa Maria Nuova

Research output: Contribution to journal › Article › peer-review

Abstract

The high cost of virgin ¹⁸O-enriched water has forced many researchers to study methods to purify and recycle enriched water after the first irradiation for the production of radiopharmaceuticals. In our study, [¹⁸O]H₂O was purified by ozonolysis and distillation. Analyses showed a large decrease in impurities after this treatment. The purification procedure was carried out after the production of 94 batches of [¹⁸F]-FDG, which were manufactured using a GE Minitrace cyclotron and a GE Mx TracerLab synthesizer. Saturation yields after bombardment, using virgin and re-purified water were, respectively, 2864±204 MBq/μA and 2727±167 MBq/μA, a decrease of 5.5%. The decrease in [¹⁸F]-FDG yield, from 67.2±0.7% to 65.5±0.9%, can be ascribed to the irradiation step only.

Original language	English
Pages (from-to)	831-835
Number of pages	5
Journal	Applied Radiation and Isotopes
Volume	65
Issue number	7
DOIs	https://doi.org/10.1016/j.apradiso.2007.03.003
Publication status	Published - Jul 2007

Keywords

[F]-FDG
[O]HO
Cyclotron
Enriched water
Radiopharmaceuticals

ASJC Scopus subject areas

Radiation

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10.1016/j.apradiso.2007.03.003

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Asti, M., Grassi, E., Sghedoni, R., De Pietri, G., Fioroni, F., Versari, A., Borasi, G., & Salvo, D. (2007). Purification by ozonolysis of 18O enriched water after cyclotron irradiation and the utilization of the purified water for the production of [18F]-FDG (2-deoxy-2-[18F]-fluoro-d-glucose). Applied Radiation and Isotopes, 65(7), 831-835. https://doi.org/10.1016/j.apradiso.2007.03.003

Purification by ozonolysis of 18O enriched water after cyclotron irradiation and the utilization of the purified water for the production of [18F]-FDG (2-deoxy-2-[18F]-fluoro-d-glucose). / Asti, M.; Grassi, E.; Sghedoni, R. et al.

In: Applied Radiation and Isotopes, Vol. 65, No. 7, 07.2007, p. 831-835.

Research output: Contribution to journal › Article › peer-review

Asti, M, Grassi, E, Sghedoni, R, De Pietri, G, Fioroni, F , Versari, A, Borasi, G & Salvo, D 2007, 'Purification by ozonolysis of 18O enriched water after cyclotron irradiation and the utilization of the purified water for the production of [18F]-FDG (2-deoxy-2-[18F]-fluoro-d-glucose)', Applied Radiation and Isotopes, vol. 65, no. 7, pp. 831-835. https://doi.org/10.1016/j.apradiso.2007.03.003

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title = "Purification by ozonolysis of 18O enriched water after cyclotron irradiation and the utilization of the purified water for the production of [18F]-FDG (2-deoxy-2-[18F]-fluoro-d-glucose)",

abstract = "The high cost of virgin 18O-enriched water has forced many researchers to study methods to purify and recycle enriched water after the first irradiation for the production of radiopharmaceuticals. In our study, [18O]H2O was purified by ozonolysis and distillation. Analyses showed a large decrease in impurities after this treatment. The purification procedure was carried out after the production of 94 batches of [18F]-FDG, which were manufactured using a GE Minitrace cyclotron and a GE Mx TracerLab synthesizer. Saturation yields after bombardment, using virgin and re-purified water were, respectively, 2864±204 MBq/μA and 2727±167 MBq/μA, a decrease of 5.5%. The decrease in [18F]-FDG yield, from 67.2±0.7% to 65.5±0.9%, can be ascribed to the irradiation step only.",

keywords = "[F]-FDG, [O]HO, Cyclotron, Enriched water, Radiopharmaceuticals",

author = "M. Asti and E. Grassi and R. Sghedoni and {De Pietri}, G. and F. Fioroni and A. Versari and G. Borasi and D. Salvo",

year = "2007",

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doi = "10.1016/j.apradiso.2007.03.003",

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AU - Asti, M.

AU - Grassi, E.

AU - Sghedoni, R.

AU - De Pietri, G.

AU - Fioroni, F.

AU - Versari, A.

AU - Borasi, G.

AU - Salvo, D.

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N2 - The high cost of virgin 18O-enriched water has forced many researchers to study methods to purify and recycle enriched water after the first irradiation for the production of radiopharmaceuticals. In our study, [18O]H2O was purified by ozonolysis and distillation. Analyses showed a large decrease in impurities after this treatment. The purification procedure was carried out after the production of 94 batches of [18F]-FDG, which were manufactured using a GE Minitrace cyclotron and a GE Mx TracerLab synthesizer. Saturation yields after bombardment, using virgin and re-purified water were, respectively, 2864±204 MBq/μA and 2727±167 MBq/μA, a decrease of 5.5%. The decrease in [18F]-FDG yield, from 67.2±0.7% to 65.5±0.9%, can be ascribed to the irradiation step only.

AB - The high cost of virgin 18O-enriched water has forced many researchers to study methods to purify and recycle enriched water after the first irradiation for the production of radiopharmaceuticals. In our study, [18O]H2O was purified by ozonolysis and distillation. Analyses showed a large decrease in impurities after this treatment. The purification procedure was carried out after the production of 94 batches of [18F]-FDG, which were manufactured using a GE Minitrace cyclotron and a GE Mx TracerLab synthesizer. Saturation yields after bombardment, using virgin and re-purified water were, respectively, 2864±204 MBq/μA and 2727±167 MBq/μA, a decrease of 5.5%. The decrease in [18F]-FDG yield, from 67.2±0.7% to 65.5±0.9%, can be ascribed to the irradiation step only.

KW - [F]-FDG

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KW - Enriched water

KW - Radiopharmaceuticals

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Purification by ozonolysis of 18O enriched water after cyclotron irradiation and the utilization of the purified water for the production of [18F]-FDG (2-deoxy-2-[18F]-fluoro-d-glucose)

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