Purification by ozonolysis of 18O enriched water after cyclotron irradiation and the utilization of the purified water for the production of [18F]-FDG (2-deoxy-2-[18F]-fluoro-d-glucose)

M. Asti, E. Grassi, R. Sghedoni, G. De Pietri, F. Fioroni, A. Versari, G. Borasi, D. Salvo

Research output: Contribution to journalArticlepeer-review

Abstract

The high cost of virgin 18O-enriched water has forced many researchers to study methods to purify and recycle enriched water after the first irradiation for the production of radiopharmaceuticals. In our study, [18O]H2O was purified by ozonolysis and distillation. Analyses showed a large decrease in impurities after this treatment. The purification procedure was carried out after the production of 94 batches of [18F]-FDG, which were manufactured using a GE Minitrace cyclotron and a GE Mx TracerLab synthesizer. Saturation yields after bombardment, using virgin and re-purified water were, respectively, 2864±204 MBq/μA and 2727±167 MBq/μA, a decrease of 5.5%. The decrease in [18F]-FDG yield, from 67.2±0.7% to 65.5±0.9%, can be ascribed to the irradiation step only.

Original languageEnglish
Pages (from-to)831-835
Number of pages5
JournalApplied Radiation and Isotopes
Volume65
Issue number7
DOIs
Publication statusPublished - Jul 2007

Keywords

  • [F]-FDG
  • [O]HO
  • Cyclotron
  • Enriched water
  • Radiopharmaceuticals

ASJC Scopus subject areas

  • Radiation

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