Purines and pyrimidines determination in urine using high-performance liquid chromatography

G. Minniti, U. Caruso, R. Cerone, E. De Toni

Research output: Contribution to journalArticlepeer-review


Single purine and pirimidine bases are involved in two fundamental metabolic pathways that lead to formation of the building stones of DNA and RNA. Purine and pyrimidine nucleotides are also critically important metabolites in many cellular functions. The main breakdown of purines and pyrimidines produces uric acid and B-minoacids, respectively. Therefore, the study of purine and pirimidine compounds in body fluid has high clinical relevance. We report, in this work, our experience in purines and pyrimidines determination in urine from children presenting with a clinical picture suggesting an inborn these pathways.

Original languageEnglish
Pages (from-to)843-848
Number of pages6
JournalAdvances in Experimental Medicine and Biology
Publication statusPublished - 1998

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)


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