Purpura as the initial presentation for small-cell lung cancer

Gabriele Zoppoli, Enrico Balleari, Andrea Bruzzone, Luca Mastracci, Riccardo Ghio

Research output: Contribution to journalArticlepeer-review


Background: Causes of thrombocytopenia (TP) in patients affected by smallcell lung cancer (SCLC) include myelophtysis, immunomediated TP, disseminated intravascular coagulation, thrombotic thrombocytopenic purpura, drugrelated TP, and amegakaryocytic TP. However, isolated TP is an exceedingly rare presentation of SCLC. Case Report: Here, we report on a 78-year-old Caucasian man with SCLC whose only clinic manifestation at the beginning of his clinical course was a diffuse purpuric rash, indeed due to severe isolated TP. A thorough clinical workup led us to the diagnosis of secondary amegakaryocytic TP, which resolved after chemotherapy. Conclusion: To the best of our knowledge, this is the first described case of SCLC presenting with amegakaryocytic TP. SCLC should be considered in the differential diagnosis of isolated TP, as should rare triggering conditions like amegakaryocytic TP when evaluating therapeutic opportunities in thrombocytopenic patients.

Original languageEnglish
Pages (from-to)277-279
Number of pages3
Issue number5
Publication statusPublished - May 2009


  • Diagnosis
  • Small-cell lung cancer
  • Therapy
  • Thrombocytopenia, amegakaryocytic

ASJC Scopus subject areas

  • Oncology
  • Cancer Research
  • Hematology


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