PUVA-treated psoriatic skin as a model for cutaneous wrinkling assessed by skin replicas

V. Brazzelli, G. Borroni, E. Berardesca, E. Romano, G. P. Vignoli, G. Rabbiosi

Research output: Contribution to journalArticle

Abstract

Psoriatic patients may offer a useful model for PUVA-induced skin wrinkling. This study deals with the changes induced by PUVA therapy on the cutaneous microrelief of psoriatic patients assessed by surface replicas. A non-exposed body area (buttocks) was considered. The microrelief was evaluated by means of replicas analysed by an automatic image analyser. Three groups of patients were considered: 1) 10 psoriatic patients who had been undergoing PUVA treatment for the first time and who had received a total PUVA dose of 200 ± 20 J/cm2; 2) 16 psoriatic patients in long-term PUVA treatment (>1000 J/cm2); 3) 13 psoriatic controls whose buttocks had never been affected by psoriasis nor exposed to sunlight or PUVA. The results showed that the number and the entity of the cutaneous crests and furrows had been increased by PUVA therapy. In particular the skin pattern analysis showed significant statistical differences between the second and the third group, while no changes were evident between the first and third group (ANOVA and Tukey test for multiple comparisons). In conclusion, our findings indicate that long-term PUVA therapy causes marked changes in the cutaneous microrelief, that this phenomenon can be measured non-invasively and that the changes observed are dependent on the PUVA-dose energies received.

Original languageEnglish
Pages (from-to)162-163
Number of pages2
JournalActa Dermato-Venereologica, Supplement
Issue number186
Publication statusPublished - 1994

Fingerprint

Skin Aging
PUVA Therapy
Skin
Buttocks
Sunlight
Psoriasis
Analysis of Variance
Therapeutics

Keywords

  • microrelief
  • psoriasis
  • PUVA therapy
  • skin replicas

ASJC Scopus subject areas

  • Dermatology

Cite this

Brazzelli, V., Borroni, G., Berardesca, E., Romano, E., Vignoli, G. P., & Rabbiosi, G. (1994). PUVA-treated psoriatic skin as a model for cutaneous wrinkling assessed by skin replicas. Acta Dermato-Venereologica, Supplement, (186), 162-163.

PUVA-treated psoriatic skin as a model for cutaneous wrinkling assessed by skin replicas. / Brazzelli, V.; Borroni, G.; Berardesca, E.; Romano, E.; Vignoli, G. P.; Rabbiosi, G.

In: Acta Dermato-Venereologica, Supplement, No. 186, 1994, p. 162-163.

Research output: Contribution to journalArticle

Brazzelli, V, Borroni, G, Berardesca, E, Romano, E, Vignoli, GP & Rabbiosi, G 1994, 'PUVA-treated psoriatic skin as a model for cutaneous wrinkling assessed by skin replicas', Acta Dermato-Venereologica, Supplement, no. 186, pp. 162-163.
Brazzelli, V. ; Borroni, G. ; Berardesca, E. ; Romano, E. ; Vignoli, G. P. ; Rabbiosi, G. / PUVA-treated psoriatic skin as a model for cutaneous wrinkling assessed by skin replicas. In: Acta Dermato-Venereologica, Supplement. 1994 ; No. 186. pp. 162-163.
@article{9fac0f533cbf42f3b0abe20c96b7f5ca,
title = "PUVA-treated psoriatic skin as a model for cutaneous wrinkling assessed by skin replicas",
abstract = "Psoriatic patients may offer a useful model for PUVA-induced skin wrinkling. This study deals with the changes induced by PUVA therapy on the cutaneous microrelief of psoriatic patients assessed by surface replicas. A non-exposed body area (buttocks) was considered. The microrelief was evaluated by means of replicas analysed by an automatic image analyser. Three groups of patients were considered: 1) 10 psoriatic patients who had been undergoing PUVA treatment for the first time and who had received a total PUVA dose of 200 ± 20 J/cm2; 2) 16 psoriatic patients in long-term PUVA treatment (>1000 J/cm2); 3) 13 psoriatic controls whose buttocks had never been affected by psoriasis nor exposed to sunlight or PUVA. The results showed that the number and the entity of the cutaneous crests and furrows had been increased by PUVA therapy. In particular the skin pattern analysis showed significant statistical differences between the second and the third group, while no changes were evident between the first and third group (ANOVA and Tukey test for multiple comparisons). In conclusion, our findings indicate that long-term PUVA therapy causes marked changes in the cutaneous microrelief, that this phenomenon can be measured non-invasively and that the changes observed are dependent on the PUVA-dose energies received.",
keywords = "microrelief, psoriasis, PUVA therapy, skin replicas",
author = "V. Brazzelli and G. Borroni and E. Berardesca and E. Romano and Vignoli, {G. P.} and G. Rabbiosi",
year = "1994",
language = "English",
pages = "162--163",
journal = "Acta Dermato-Venereologica, Supplement",
issn = "0365-8341",
publisher = "Society for the Publication of Acta Dermato-Venereologica",
number = "186",

}

TY - JOUR

T1 - PUVA-treated psoriatic skin as a model for cutaneous wrinkling assessed by skin replicas

AU - Brazzelli, V.

AU - Borroni, G.

AU - Berardesca, E.

AU - Romano, E.

AU - Vignoli, G. P.

AU - Rabbiosi, G.

PY - 1994

Y1 - 1994

N2 - Psoriatic patients may offer a useful model for PUVA-induced skin wrinkling. This study deals with the changes induced by PUVA therapy on the cutaneous microrelief of psoriatic patients assessed by surface replicas. A non-exposed body area (buttocks) was considered. The microrelief was evaluated by means of replicas analysed by an automatic image analyser. Three groups of patients were considered: 1) 10 psoriatic patients who had been undergoing PUVA treatment for the first time and who had received a total PUVA dose of 200 ± 20 J/cm2; 2) 16 psoriatic patients in long-term PUVA treatment (>1000 J/cm2); 3) 13 psoriatic controls whose buttocks had never been affected by psoriasis nor exposed to sunlight or PUVA. The results showed that the number and the entity of the cutaneous crests and furrows had been increased by PUVA therapy. In particular the skin pattern analysis showed significant statistical differences between the second and the third group, while no changes were evident between the first and third group (ANOVA and Tukey test for multiple comparisons). In conclusion, our findings indicate that long-term PUVA therapy causes marked changes in the cutaneous microrelief, that this phenomenon can be measured non-invasively and that the changes observed are dependent on the PUVA-dose energies received.

AB - Psoriatic patients may offer a useful model for PUVA-induced skin wrinkling. This study deals with the changes induced by PUVA therapy on the cutaneous microrelief of psoriatic patients assessed by surface replicas. A non-exposed body area (buttocks) was considered. The microrelief was evaluated by means of replicas analysed by an automatic image analyser. Three groups of patients were considered: 1) 10 psoriatic patients who had been undergoing PUVA treatment for the first time and who had received a total PUVA dose of 200 ± 20 J/cm2; 2) 16 psoriatic patients in long-term PUVA treatment (>1000 J/cm2); 3) 13 psoriatic controls whose buttocks had never been affected by psoriasis nor exposed to sunlight or PUVA. The results showed that the number and the entity of the cutaneous crests and furrows had been increased by PUVA therapy. In particular the skin pattern analysis showed significant statistical differences between the second and the third group, while no changes were evident between the first and third group (ANOVA and Tukey test for multiple comparisons). In conclusion, our findings indicate that long-term PUVA therapy causes marked changes in the cutaneous microrelief, that this phenomenon can be measured non-invasively and that the changes observed are dependent on the PUVA-dose energies received.

KW - microrelief

KW - psoriasis

KW - PUVA therapy

KW - skin replicas

UR - http://www.scopus.com/inward/record.url?scp=0028185802&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0028185802&partnerID=8YFLogxK

M3 - Article

C2 - 8073823

AN - SCOPUS:0028185802

SP - 162

EP - 163

JO - Acta Dermato-Venereologica, Supplement

JF - Acta Dermato-Venereologica, Supplement

SN - 0365-8341

IS - 186

ER -