TY - JOUR
T1 - Pyoderma gangrenosum complicating ulcerative colitis
T2 - An alternative treatment with iloprost
AU - Mazzone, Antonino
AU - Cusa, Chiara
AU - Mazzucchelli, Iolanda
AU - Rosso, Renato
AU - Vezzoli, Monia
PY - 1999
Y1 - 1999
N2 - This paper describes 2 patients with pyoderma gangrenosum (PG) as a complication of ulcerative colitis; both cases were treated successfully with a prostaglandin I
2 (PGI
2) analogue (Iloprost) administered by intravenous infusion. The cutaneous lesions of PG usually heal slowly, leaving disfiguring scars. Evidence suggests that phagocyte cell dysfunction, combined with increased interactions between these cells and endothelial cells, plays a pivotal role in PG pathogenesis. High-dose corticosteroids are usually effective; however, alternative treatments have also been studied. The PGI
2 analogue induces an elective microvascular vasodilation and downregulates phagocyte adhesion molecule expression, improving microvascular blood flow. The 2 patients were treated with the PGI
2 analogue for 14 consecutive days. Both of the ulcerated areas healed completely after 14 days, and the recovery was confirmed after 2 years of follow-up. This drug increases microvascular capacity and can be considered as an alternative treatment for PG lesions.
AB - This paper describes 2 patients with pyoderma gangrenosum (PG) as a complication of ulcerative colitis; both cases were treated successfully with a prostaglandin I
2 (PGI
2) analogue (Iloprost) administered by intravenous infusion. The cutaneous lesions of PG usually heal slowly, leaving disfiguring scars. Evidence suggests that phagocyte cell dysfunction, combined with increased interactions between these cells and endothelial cells, plays a pivotal role in PG pathogenesis. High-dose corticosteroids are usually effective; however, alternative treatments have also been studied. The PGI
2 analogue induces an elective microvascular vasodilation and downregulates phagocyte adhesion molecule expression, improving microvascular blood flow. The 2 patients were treated with the PGI
2 analogue for 14 consecutive days. Both of the ulcerated areas healed completely after 14 days, and the recovery was confirmed after 2 years of follow-up. This drug increases microvascular capacity and can be considered as an alternative treatment for PG lesions.
KW - Antiadhesion therapy
KW - Microcirculation
KW - Pyoderma gangrenosum
KW - Ulcerative colitis
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U2 - 10.1016/S0011-393X(99)80012-5
DO - 10.1016/S0011-393X(99)80012-5
M3 - Article
AN - SCOPUS:0032869442
VL - 60
SP - 357
EP - 362
JO - Current Therapeutic Research - Clinical and Experimental
JF - Current Therapeutic Research - Clinical and Experimental
SN - 0011-393X
IS - 6
ER -