Pyoderma gangrenosum complicating ulcerative colitis: An alternative treatment with iloprost

Antonino Mazzone, Chiara Cusa, Iolanda Mazzucchelli, Renato Rosso, Monia Vezzoli

Research output: Contribution to journalArticlepeer-review


This paper describes 2 patients with pyoderma gangrenosum (PG) as a complication of ulcerative colitis; both cases were treated successfully with a prostaglandin I 2 (PGI 2) analogue (Iloprost) administered by intravenous infusion. The cutaneous lesions of PG usually heal slowly, leaving disfiguring scars. Evidence suggests that phagocyte cell dysfunction, combined with increased interactions between these cells and endothelial cells, plays a pivotal role in PG pathogenesis. High-dose corticosteroids are usually effective; however, alternative treatments have also been studied. The PGI 2 analogue induces an elective microvascular vasodilation and downregulates phagocyte adhesion molecule expression, improving microvascular blood flow. The 2 patients were treated with the PGI 2 analogue for 14 consecutive days. Both of the ulcerated areas healed completely after 14 days, and the recovery was confirmed after 2 years of follow-up. This drug increases microvascular capacity and can be considered as an alternative treatment for PG lesions.

Original languageEnglish
Pages (from-to)357-362
Number of pages6
JournalCurrent Therapeutic Research
Issue number6
Publication statusPublished - 1999


  • Antiadhesion therapy
  • Microcirculation
  • Pyoderma gangrenosum
  • Ulcerative colitis

ASJC Scopus subject areas

  • Medicine(all)


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