Pyogenic granuloma stimulates angiogenesis in the chick embryo chorioallantoic membrane

D. Ribatti, A. Vacca, G. Schiraldi, S. Sorino, F. Caprio, F. Mazzotta, L. Roncali, E. Bonifazi

Research output: Contribution to journalArticlepeer-review


Ten samples of pyogenic granuloma and 10 of normal skin from age- and sex-matched controls were grafted onto the chick embryo chorioallantoic membrane (CAM) to investigate their possible angiogenic activity. The angiogenic response in pathological and control implants was assessed on histologic sections by a planimetric point-count method 4 days after grafting. The CAM mast cells were also quantified. The vascular counts in the area underlying the pyogenic granuloma were four times higher than those of normal skin. A higher number of mucosa-like mast cells was detected in the intermediate mesenchyme of the CAM in pathological samples in comparison to controls. Pyogenic granuloma may promote angiogenesis leading to release of several angiogenic factors. The role played in angiogenic response by the inflammatory cells, mainly mast cells, forming the perilesional infiltrate was supported by this study.

Original languageEnglish
Pages (from-to)82-88
Number of pages7
JournalInternational journal of microcirculation, clinical and experimental / sponsored by the European Society for Microcirculation
Issue number2
Publication statusPublished - Mar 1996


  • Angiogenesis
  • Angioma
  • Chorioallantoic membrane
  • Mast cells
  • Vasoproliferative processes

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Physiology


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