Pyrogenic cytokine interleukin-6 expression by a chordoid meningioma in an adult with a systemic inflammatory syndrome

Luca Denaro, Federico Di Rocco, Marco Gessi, Libero Lauriola, Liverana Lauretti, Roberto Pallini, Eduardo Fernandez, Giulio Maira

Research output: Contribution to journalArticlepeer-review

Abstract

Chordoid meningioma is a rare meningothelial tumor characterized by chordoma-like histological features with lymphoplasmacellular infiltration. This tumor is often seen in children, but not in adults, with a systemic inflammatory syndrome (iron-resistant microcytic anemia and/or dysgammaglobulinemia) and very rarely with a persistent moderate hyperthermia. In the present report the authors describe a temporal chordoid meningioma in a 30-year-old woman who presented with fever, headache, and a serological inflammatory syndrome. The clinical symptomatology, chiefly the fever, disappeared immediately after removal of the tumor. To the authors' knowledge, only one similar patient with such clinical presentation and response to surgery has been mentioned in the literature. Interestingly, at immunohistochemical examination, the neoplasm showed focal positivity for the pyrogenic cytokine interleukin-6. The capacity of the tumor to produce this pyrogenic cytokine could explain both the patient's clinical presentation and her response to the surgical management.

Original languageEnglish
Pages (from-to)555-558
Number of pages4
JournalJournal of Neurosurgery
Volume103
Issue number3
DOIs
Publication statusPublished - Sep 2005

Keywords

  • Chordoid meningioma
  • Inflammatory syndrome
  • Interleukin-6
  • Pyrogenic cytokine
  • Tumor necrosis factor

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)

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