QRS duration in left bundle branch block does not affect left ventricular twisting in chronic systolic heart failure

Paola Attanà, Alessandro Paoletti Perini, Carmine Domenico Votta, Francesco Cappelli, Paolo Pieragnoli, Giuseppe Ricciardi, Martina Nesti, Andrea Giomi, Stefania Sacchi, Marco Chiostri, Luigi Padeletti

Research output: Contribution to journalArticlepeer-review


Purpose: Left ventricular (LV) torsion is an important parameter of LV performance and can be influenced by several factors. Aim of this investigation was to evaluate whether QRS prolongation in left bundle branch block (LBBB) may influence global LV twist and twisting/untwisting rate in chronic systolic heart failure (HF) patients. Methods: We prospectively evaluated 30 healthy subjects (control group) and 100 chronic HF patients with severely impaired LV systolic function (ejection fraction ≤35%). Patients were divided into three groups according to QRS duration: A: QRS <120 ms (n 49), B: 120 ≤ QRS ≤ 150 ms (n 28) and C: QRS > 150 ms (n 23). Patients in groups B and C presented LBBB. All subjects underwent standard trans-thoracic echocardiography and two-dimensional speckle-tracking echocardiography evaluation. Categorical variables were compared by the chi-square or the Fisher's exact test. Continuous variables were compared using the ANOVA test. Correlations between variables were analysed with linear regression. Results: Control subjects presented higher torsion parameters, when compared with patients in any HF group. Among the three HF groups, no differences were detected in global twist (4·79 ± 3·54, 3·8 ± 3·0 and 4·15 ± 3·14 degrees, respectively), twist rate max (44·81 ± 25·03, 37·94 ± 19·09 and 37·61 ± 24·49 degrees s-1, respectively) and untwist rate max (-36·31 ± 30·89, -27·68 ± 34·67 and -39·62 ± 26·27 degrees s-1, respectively) (P>0·05 for all). At linear regression analysis, there was no relation between QRS duration and any torsion parameter (P>0·05 for all). Conclusions: In patients with chronic severe systolic heart failure, QRS duration and LBBB morphology do not affect LV twisting and untwisting.

Original languageEnglish
Pages (from-to)436-442
Number of pages7
JournalClinical Physiology and Functional Imaging
Issue number6
Publication statusPublished - Nov 1 2015


  • Heart failure
  • Left bundle branch block
  • Left ventricular twist
  • QRS duration
  • Speckle-tracking echocardiography

ASJC Scopus subject areas

  • Physiology
  • Physiology (medical)


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