(Q)SAR methods for predicting genotoxicity and carcinogenicity: Scientific rationale and regulatory frameworks

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Knowledge of the genotoxicity and carcinogenicity potential of chemical substances is one of the key scientific elements able to better protect human health. Genotoxicity assessment is also considered as prescreening of carcinogenicity. The assessment of both endpoints is a fundamental component of national and international legislations, for all types of substances, and has stimulated the development of alternative, nontesting methods. Over the recent decades, much attention has been given to the use and further development of structure–activity relationships-based approaches, to be used in isolation or in combination with in vitro assays for predictive purposes. In this chapter, we briefly introduce the rationale for the main (Q)SAR approaches, and detail the most important regulatory initiatives and frameworks. It appears that the existence and needs of regulatory frameworks stimulate the development of better predictive tools; in turn, this allows the regulators to fine-tune their requirements for an improved defense of human health.

Original languageEnglish
Title of host publicationMethods in Molecular Biology
PublisherHumana Press Inc.
Pages447-473
Number of pages27
DOIs
Publication statusPublished - Jan 1 2018

Publication series

NameMethods in Molecular Biology
Volume1800
ISSN (Print)1064-3745

Keywords

  • Alternative testing
  • Carcinogenicity
  • Expert systems
  • Genotoxicity
  • Human health
  • Predictive toxicology
  • QSAR
  • Structure–activity relationship

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics

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