TY - CHAP
T1 - (Q)SAR methods for predicting genotoxicity and carcinogenicity
T2 - Scientific rationale and regulatory frameworks
AU - Bossa, Cecilia
AU - Benigni, Romualdo
AU - Tcheremenskaia, Olga
AU - Battistelli, Chiara Laura
PY - 2018/1/1
Y1 - 2018/1/1
N2 - Knowledge of the genotoxicity and carcinogenicity potential of chemical substances is one of the key scientific elements able to better protect human health. Genotoxicity assessment is also considered as prescreening of carcinogenicity. The assessment of both endpoints is a fundamental component of national and international legislations, for all types of substances, and has stimulated the development of alternative, nontesting methods. Over the recent decades, much attention has been given to the use and further development of structure–activity relationships-based approaches, to be used in isolation or in combination with in vitro assays for predictive purposes. In this chapter, we briefly introduce the rationale for the main (Q)SAR approaches, and detail the most important regulatory initiatives and frameworks. It appears that the existence and needs of regulatory frameworks stimulate the development of better predictive tools; in turn, this allows the regulators to fine-tune their requirements for an improved defense of human health.
AB - Knowledge of the genotoxicity and carcinogenicity potential of chemical substances is one of the key scientific elements able to better protect human health. Genotoxicity assessment is also considered as prescreening of carcinogenicity. The assessment of both endpoints is a fundamental component of national and international legislations, for all types of substances, and has stimulated the development of alternative, nontesting methods. Over the recent decades, much attention has been given to the use and further development of structure–activity relationships-based approaches, to be used in isolation or in combination with in vitro assays for predictive purposes. In this chapter, we briefly introduce the rationale for the main (Q)SAR approaches, and detail the most important regulatory initiatives and frameworks. It appears that the existence and needs of regulatory frameworks stimulate the development of better predictive tools; in turn, this allows the regulators to fine-tune their requirements for an improved defense of human health.
KW - Alternative testing
KW - Carcinogenicity
KW - Expert systems
KW - Genotoxicity
KW - Human health
KW - Predictive toxicology
KW - QSAR
KW - Structure–activity relationship
UR - http://www.scopus.com/inward/record.url?scp=85049052292&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85049052292&partnerID=8YFLogxK
U2 - 10.1007/978-1-4939-7899-1_20
DO - 10.1007/978-1-4939-7899-1_20
M3 - Chapter
C2 - 29934905
AN - SCOPUS:85049052292
T3 - Methods in Molecular Biology
SP - 447
EP - 473
BT - Methods in Molecular Biology
PB - Humana Press Inc.
ER -