Abstract
The possibility of building up predictive model for cytotoxicity of SiO2-nanoparticles (SiO2-NPs) by means of so-called optimal descriptors which are mathematical functions of size and concentration of SiO2-NPs is demonstrated with data on sixteen systems' "size-concentration." The calculation has been carried out by means of the CORAL software (http://www.insilico.eu/coral/). The statistical quality of the best model for the cytotoxic inhibition ratio (%) of human lung fibroblasts cultured in the media containing different concentrations of SiO 2â€.
Original language | English |
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Article number | 2282 |
Journal | Journal of Nanoparticle Research |
Volume | 16 |
Issue number | 2 |
DOIs | |
Publication status | Published - Feb 2014 |
Keywords
- CORAL software
- Health effects
- Modeling and simulation
- Optimal descriptor
- QSAR
- SiO nanoparticle
ASJC Scopus subject areas
- Atomic and Molecular Physics, and Optics
- Condensed Matter Physics
- Modelling and Simulation
- Chemistry(all)
- Materials Science(all)
- Bioengineering