QSAR model for cytotoxicity of SiO2 nanoparticles on human lung fibroblasts

Alla P. Toropova; Andrey A. Toropov; Emilio Benfenati; Rafi Korenstein

doi:10.1007/s11051-014-2282-9

QSAR model for cytotoxicity of SiO₂ nanoparticles on human lung fibroblasts

Alla P. Toropova, Andrey A. Toropov, Emilio Benfenati, Rafi Korenstein

Istituto di Ricerche Farmacologiche "Mario Negri"

Research output: Contribution to journal › Article › peer-review

Abstract

The possibility of building up predictive model for cytotoxicity of SiO₂-nanoparticles (SiO₂-NPs) by means of so-called optimal descriptors which are mathematical functions of size and concentration of SiO₂-NPs is demonstrated with data on sixteen systems' "size-concentration." The calculation has been carried out by means of the CORAL software (http://www.insilico.eu/coral/). The statistical quality of the best model for the cytotoxic inhibition ratio (%) of human lung fibroblasts cultured in the media containing different concentrations of SiO ₂â€.

Original language	English
Article number	2282
Journal	Journal of Nanoparticle Research
Volume	16
Issue number	2
DOIs	https://doi.org/10.1007/s11051-014-2282-9
Publication status	Published - Feb 2014

Keywords

CORAL software
Health effects
Modeling and simulation
Optimal descriptor
QSAR
SiO nanoparticle

ASJC Scopus subject areas

Atomic and Molecular Physics, and Optics
Condensed Matter Physics
Modelling and Simulation
Chemistry(all)
Materials Science(all)
Bioengineering

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AU - Toropova, Alla P.

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AU - Benfenati, Emilio

AU - Korenstein, Rafi

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