QSAR models for Daphnia magna toxicity prediction of benzoxazinone allelochemicals and their transformation products

Elena Lo Piparo, Filip Fratev, Frank Lemke, Paolo Mazzatorta, Martin Smiesko, Jona Ines Fritz, Emilio Benfenati

Research output: Contribution to journalArticle

Abstract

The overall objective of this study is the ecotoxicological characterization of the benzoxazinone 2,4-dihydroxy-7-methoxy-1,4-benzoxazin-3- one (DIMBOA), the benzoxazolinones benzoxazolin-2-one (BOA) and 6-methoxybenzoxazolin-2-one (MBOA), and their transformation products: phenoxazinones 2-acetylamino-7-methoxy-3H-phenoxazin-3-one (AAMPO), 2-acetylamino-3H-phenoxazin-3-one (AAPO), 2-amino-7-methoxy-3H-phenoxazin-3-one (AMPO), and 2-amino-3H-phenoxazin-3-one (APO); aminophenol 2-aminophenol AP); acetamide N-(2-hydroxyphenyl)acetamide (HPAA); and malonamic acid amide N-(2-hydroxyphenyl)malonamic acid (HPMA). A comparison between empirical results and theoretical ones using rules-based prediction of toxicity was done, and it can be concluded that only the degradation metabolites exhibited significant ecotoxic effect. Using synthetic pesticides knowledge, several QSAR models were trained with various approaches and descriptors. The models generated exhibited good internal predictive ability (Rcv 2 > 0.6) and were used to predict the toxicity of the natural compounds studied.

Original languageEnglish
Pages (from-to)1111-1115
Number of pages5
JournalJournal of Agricultural and Food Chemistry
Volume54
Issue number4
DOIs
Publication statusPublished - Feb 22 2006

Keywords

  • Aquatic ecotoxicity
  • Benzoxazinones
  • Daphnia magna
  • EC
  • QSAR

ASJC Scopus subject areas

  • Agricultural and Biological Sciences (miscellaneous)
  • Food Science
  • Chemistry (miscellaneous)

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