Quadriceps Strength as a Predictor of Mortality in Coronary Artery Disease

Kentaro Kamiya, Takashi Masuda, Shinya Tanaka, Nobuaki Hamazaki, Yuya Matsue, Alessandro Mezzani, Ryota Matsuzawa, Kohei Nozaki, Emi Maekawa, Chiharu Noda, Minako Yamaoka-Tojo, Yasuo Arai, Atsuhiko Matsunaga, Tohru Izumi, Junya Ako

Research output: Contribution to journalArticlepeer-review


Background The purpose of this study was to investigate the prognostic value of quadriceps isometric strength (QIS) in coronary artery disease (CAD). Methods The study population consisted of 1314 patients aged >30 years (64.7 ± 10.6 years, 1051 male) with CAD who were hospitalized for acute coronary syndrome or coronary artery bypass grafting. Maximal QIS was evaluated as a marker of leg strength and expressed relative to body weight (% body weight). The primary and secondary endpoints were all-cause death and cardiovascular (CV) death, respectively. Results During a mean follow-up of 5.0 ± 3.5 years, corresponding to 6537 person-years, there were 118 all-cause deaths and 63 CV deaths. A higher QIS remained associated with decreased all-cause mortality and CV mortality risks (hazard ratio for increasing 10% body weight of QIS 0.77, 95% confidence interval 0.67-0.89, P

Original languageEnglish
Pages (from-to)1212-1219
Number of pages8
JournalAmerican Journal of Medicine
Issue number11
Publication statusPublished - Nov 1 2015


  • Coronary artery disease
  • Muscle strength
  • Prognosis

ASJC Scopus subject areas

  • Medicine(all)


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