Qualitative immune modulation by interleukin-2 (IL-2) adjuvant therapy in immunological non responder HIV-infected patients

Francesca Sabbatini, Alessandra Bandera, Giulio Ferrario, Daria Trabattoni, Giulia Marchetti, Fabio Franzetti, Mario Clerici, Andrea Gori

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Background: Treatment of HIV-infected patients with interleukin-2 (IL-2) produces significant increases in CD4 T cell counts; however an associated qualitative improvement in cells function has yet to be conclusively demonstrated. By measuring mycobacterial killing activity, we evaluated IL-2-mediated functional immune enhancement ex vivo in immunological nonresponders (INRs). Methods and Findings: PBMC from 12 immunological non-responders (INRs) (CD4+

Original languageEnglish
Article numbere14119
JournalPLoS One
Volume5
Issue number11
DOIs
Publication statusPublished - 2010

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interleukin-2
adjuvants
Interleukin-2
Modulation
HIV
therapeutics
T-cells
CD4 Lymphocyte Count
mononuclear leukocytes
T-lymphocytes
T-Lymphocytes
Therapeutics
cells
methodology

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

Cite this

Sabbatini, F., Bandera, A., Ferrario, G., Trabattoni, D., Marchetti, G., Franzetti, F., ... Gori, A. (2010). Qualitative immune modulation by interleukin-2 (IL-2) adjuvant therapy in immunological non responder HIV-infected patients. PLoS One, 5(11), [e14119]. https://doi.org/10.1371/journal.pone.0014119

Qualitative immune modulation by interleukin-2 (IL-2) adjuvant therapy in immunological non responder HIV-infected patients. / Sabbatini, Francesca; Bandera, Alessandra; Ferrario, Giulio; Trabattoni, Daria; Marchetti, Giulia; Franzetti, Fabio; Clerici, Mario; Gori, Andrea.

In: PLoS One, Vol. 5, No. 11, e14119, 2010.

Research output: Contribution to journalArticle

Sabbatini, F, Bandera, A, Ferrario, G, Trabattoni, D, Marchetti, G, Franzetti, F, Clerici, M & Gori, A 2010, 'Qualitative immune modulation by interleukin-2 (IL-2) adjuvant therapy in immunological non responder HIV-infected patients', PLoS One, vol. 5, no. 11, e14119. https://doi.org/10.1371/journal.pone.0014119
Sabbatini, Francesca ; Bandera, Alessandra ; Ferrario, Giulio ; Trabattoni, Daria ; Marchetti, Giulia ; Franzetti, Fabio ; Clerici, Mario ; Gori, Andrea. / Qualitative immune modulation by interleukin-2 (IL-2) adjuvant therapy in immunological non responder HIV-infected patients. In: PLoS One. 2010 ; Vol. 5, No. 11.
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