Abstract
Background: Treatment of HIV-infected patients with interleukin-2 (IL-2) produces significant increases in CD4 T cell counts; however an associated qualitative improvement in cells function has yet to be conclusively demonstrated. By measuring mycobacterial killing activity, we evaluated IL-2-mediated functional immune enhancement ex vivo in immunological nonresponders (INRs). Methods and Findings: PBMC from 12 immunological non-responders (INRs) (CD4+
| Original language | English |
|---|---|
| Article number | e14119 |
| Journal | PLoS One |
| Volume | 5 |
| Issue number | 11 |
| DOIs | |
| Publication status | Published - 2010 |
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ASJC Scopus subject areas
- Agricultural and Biological Sciences(all)
- Biochemistry, Genetics and Molecular Biology(all)
- Medicine(all)
Cite this
Qualitative immune modulation by interleukin-2 (IL-2) adjuvant therapy in immunological non responder HIV-infected patients. / Sabbatini, Francesca; Bandera, Alessandra; Ferrario, Giulio; Trabattoni, Daria; Marchetti, Giulia; Franzetti, Fabio; Clerici, Mario; Gori, Andrea.
In: PLoS One, Vol. 5, No. 11, e14119, 2010.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Qualitative immune modulation by interleukin-2 (IL-2) adjuvant therapy in immunological non responder HIV-infected patients
AU - Sabbatini, Francesca
AU - Bandera, Alessandra
AU - Ferrario, Giulio
AU - Trabattoni, Daria
AU - Marchetti, Giulia
AU - Franzetti, Fabio
AU - Clerici, Mario
AU - Gori, Andrea
PY - 2010
Y1 - 2010
N2 - Background: Treatment of HIV-infected patients with interleukin-2 (IL-2) produces significant increases in CD4 T cell counts; however an associated qualitative improvement in cells function has yet to be conclusively demonstrated. By measuring mycobacterial killing activity, we evaluated IL-2-mediated functional immune enhancement ex vivo in immunological nonresponders (INRs). Methods and Findings: PBMC from 12 immunological non-responders (INRs) (CD4+
AB - Background: Treatment of HIV-infected patients with interleukin-2 (IL-2) produces significant increases in CD4 T cell counts; however an associated qualitative improvement in cells function has yet to be conclusively demonstrated. By measuring mycobacterial killing activity, we evaluated IL-2-mediated functional immune enhancement ex vivo in immunological nonresponders (INRs). Methods and Findings: PBMC from 12 immunological non-responders (INRs) (CD4+
UR - http://www.scopus.com/inward/record.url?scp=78649747998&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=78649747998&partnerID=8YFLogxK
U2 - 10.1371/journal.pone.0014119
DO - 10.1371/journal.pone.0014119
M3 - Article
VL - 5
JO - PLoS One
JF - PLoS One
SN - 1932-6203
IS - 11
M1 - e14119
ER -