Qualitative immune modulation by interleukin-2 (IL-2) adjuvant therapy in immunological non responder HIV-infected patients

Francesca Sabbatini; Alessandra Bandera; Giulio Ferrario; Daria Trabattoni; Giulia Marchetti; Fabio Franzetti; Mario Clerici; Andrea Gori

doi:10.1371/journal.pone.0014119

Qualitative immune modulation by interleukin-2 (IL-2) adjuvant therapy in immunological non responder HIV-infected patients

Francesca Sabbatini, Alessandra Bandera, Giulio Ferrario, Daria Trabattoni, Giulia Marchetti, Fabio Franzetti, Mario Clerici, Andrea Gori

Fondazione Don Carlo Gnocchi Onlus

Research output: Contribution to journal › Article › peer-review

Abstract

Background: Treatment of HIV-infected patients with interleukin-2 (IL-2) produces significant increases in CD4 T cell counts; however an associated qualitative improvement in cells function has yet to be conclusively demonstrated. By measuring mycobacterial killing activity, we evaluated IL-2-mediated functional immune enhancement ex vivo in immunological nonresponders (INRs). Methods and Findings: PBMC from 12 immunological non-responders (INRs) (CD4+

Original language	English
Article number	e14119
Journal	PLoS One
Volume	5
Issue number	11
DOIs	https://doi.org/10.1371/journal.pone.0014119
Publication status	Published - 2010

ASJC Scopus subject areas

Agricultural and Biological Sciences(all)
Biochemistry, Genetics and Molecular Biology(all)
Medicine(all)

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10.1371/journal.pone.0014119

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Qualitative immune modulation by interleukin-2 (IL-2) adjuvant therapy in immunological non responder HIV-infected patients. / Sabbatini, Francesca; Bandera, Alessandra; Ferrario, Giulio; Trabattoni, Daria; Marchetti, Giulia; Franzetti, Fabio; Clerici, Mario; Gori, Andrea.

In: PLoS One, Vol. 5, No. 11, e14119, 2010.

Research output: Contribution to journal › Article › peer-review

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Qualitative immune modulation by interleukin-2 (IL-2) adjuvant therapy in immunological non responder HIV-infected patients

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