Qualitative MRI findings in patients with schizophrenia

a controlled study

Silvana Galderisi, Antonio Vita, Alessandro Rossi, Paolo Stratta, Marco Leonardi, Mario Maj, Giordano Invernizzi

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

A variety of brain structural abnormalities, which can be identified only by qualitative methods, have been shown to correlate with clinical presentation and course of schizophrenia. In the present study, MRI scans of 122 patients with DSM-IV schizophrenia and 81 non-psychiatric controls were evaluated. Among males, the frequency of CNS developmental abnormalities (CDAs) was higher in patients than in controls. Lateral ventricular enlargement (LVE) was more frequent in patients than in controls; when subjects were grouped in three age classes, LVE was more frequent in patients than in controls in the youngest and the oldest age group. Patients with LVE or third VE were older than those without these abnormalities. Schizophrenic patients with LVE or cortical atrophy (CA) had a longer duration of illness than those without these abnormalities. Both patients with LVE and those with third VE had a poorer outcome than those without these abnormalities. CDA findings add to the evidence of a higher frequency of neurodevelopmental abnormalities in male schizophrenic patients. Results concerning LVE suggest that both developmental and degenerative processes underlie this abnormality. The association of LVE and third VE with a poor outcome indicates that qualitative MRI evaluation might be of clinical relevance. Copyright (C) 2000 Elsevier Science Ireland Ltd.

Original languageEnglish
Pages (from-to)117-126
Number of pages10
JournalPsychiatry Research - Neuroimaging
Volume98
Issue number2
DOIs
Publication statusPublished - Apr 10 2000

Fingerprint

Schizophrenia
Diagnostic and Statistical Manual of Mental Disorders
Atrophy
Age Groups
Magnetic Resonance Imaging
Brain

Keywords

  • Chronicity
  • CNS developmental abnormalities
  • Outcome
  • Structural brain abnormalities

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Radiology Nuclear Medicine and imaging
  • Biological Psychiatry
  • Psychology(all)

Cite this

Galderisi, S., Vita, A., Rossi, A., Stratta, P., Leonardi, M., Maj, M., & Invernizzi, G. (2000). Qualitative MRI findings in patients with schizophrenia: a controlled study. Psychiatry Research - Neuroimaging, 98(2), 117-126. https://doi.org/10.1016/S0925-4927(00)00047-0

Qualitative MRI findings in patients with schizophrenia : a controlled study. / Galderisi, Silvana; Vita, Antonio; Rossi, Alessandro; Stratta, Paolo; Leonardi, Marco; Maj, Mario; Invernizzi, Giordano.

In: Psychiatry Research - Neuroimaging, Vol. 98, No. 2, 10.04.2000, p. 117-126.

Research output: Contribution to journalArticle

Galderisi, S, Vita, A, Rossi, A, Stratta, P, Leonardi, M, Maj, M & Invernizzi, G 2000, 'Qualitative MRI findings in patients with schizophrenia: a controlled study', Psychiatry Research - Neuroimaging, vol. 98, no. 2, pp. 117-126. https://doi.org/10.1016/S0925-4927(00)00047-0
Galderisi, Silvana ; Vita, Antonio ; Rossi, Alessandro ; Stratta, Paolo ; Leonardi, Marco ; Maj, Mario ; Invernizzi, Giordano. / Qualitative MRI findings in patients with schizophrenia : a controlled study. In: Psychiatry Research - Neuroimaging. 2000 ; Vol. 98, No. 2. pp. 117-126.
@article{cde3620cfd9147f8847f0d1aebe4ddd0,
title = "Qualitative MRI findings in patients with schizophrenia: a controlled study",
abstract = "A variety of brain structural abnormalities, which can be identified only by qualitative methods, have been shown to correlate with clinical presentation and course of schizophrenia. In the present study, MRI scans of 122 patients with DSM-IV schizophrenia and 81 non-psychiatric controls were evaluated. Among males, the frequency of CNS developmental abnormalities (CDAs) was higher in patients than in controls. Lateral ventricular enlargement (LVE) was more frequent in patients than in controls; when subjects were grouped in three age classes, LVE was more frequent in patients than in controls in the youngest and the oldest age group. Patients with LVE or third VE were older than those without these abnormalities. Schizophrenic patients with LVE or cortical atrophy (CA) had a longer duration of illness than those without these abnormalities. Both patients with LVE and those with third VE had a poorer outcome than those without these abnormalities. CDA findings add to the evidence of a higher frequency of neurodevelopmental abnormalities in male schizophrenic patients. Results concerning LVE suggest that both developmental and degenerative processes underlie this abnormality. The association of LVE and third VE with a poor outcome indicates that qualitative MRI evaluation might be of clinical relevance. Copyright (C) 2000 Elsevier Science Ireland Ltd.",
keywords = "Chronicity, CNS developmental abnormalities, Outcome, Structural brain abnormalities",
author = "Silvana Galderisi and Antonio Vita and Alessandro Rossi and Paolo Stratta and Marco Leonardi and Mario Maj and Giordano Invernizzi",
year = "2000",
month = "4",
day = "10",
doi = "10.1016/S0925-4927(00)00047-0",
language = "English",
volume = "98",
pages = "117--126",
journal = "Psychiatry Research - Neuroimaging",
issn = "0925-4927",
publisher = "Elsevier Ireland Ltd",
number = "2",

}

TY - JOUR

T1 - Qualitative MRI findings in patients with schizophrenia

T2 - a controlled study

AU - Galderisi, Silvana

AU - Vita, Antonio

AU - Rossi, Alessandro

AU - Stratta, Paolo

AU - Leonardi, Marco

AU - Maj, Mario

AU - Invernizzi, Giordano

PY - 2000/4/10

Y1 - 2000/4/10

N2 - A variety of brain structural abnormalities, which can be identified only by qualitative methods, have been shown to correlate with clinical presentation and course of schizophrenia. In the present study, MRI scans of 122 patients with DSM-IV schizophrenia and 81 non-psychiatric controls were evaluated. Among males, the frequency of CNS developmental abnormalities (CDAs) was higher in patients than in controls. Lateral ventricular enlargement (LVE) was more frequent in patients than in controls; when subjects were grouped in three age classes, LVE was more frequent in patients than in controls in the youngest and the oldest age group. Patients with LVE or third VE were older than those without these abnormalities. Schizophrenic patients with LVE or cortical atrophy (CA) had a longer duration of illness than those without these abnormalities. Both patients with LVE and those with third VE had a poorer outcome than those without these abnormalities. CDA findings add to the evidence of a higher frequency of neurodevelopmental abnormalities in male schizophrenic patients. Results concerning LVE suggest that both developmental and degenerative processes underlie this abnormality. The association of LVE and third VE with a poor outcome indicates that qualitative MRI evaluation might be of clinical relevance. Copyright (C) 2000 Elsevier Science Ireland Ltd.

AB - A variety of brain structural abnormalities, which can be identified only by qualitative methods, have been shown to correlate with clinical presentation and course of schizophrenia. In the present study, MRI scans of 122 patients with DSM-IV schizophrenia and 81 non-psychiatric controls were evaluated. Among males, the frequency of CNS developmental abnormalities (CDAs) was higher in patients than in controls. Lateral ventricular enlargement (LVE) was more frequent in patients than in controls; when subjects were grouped in three age classes, LVE was more frequent in patients than in controls in the youngest and the oldest age group. Patients with LVE or third VE were older than those without these abnormalities. Schizophrenic patients with LVE or cortical atrophy (CA) had a longer duration of illness than those without these abnormalities. Both patients with LVE and those with third VE had a poorer outcome than those without these abnormalities. CDA findings add to the evidence of a higher frequency of neurodevelopmental abnormalities in male schizophrenic patients. Results concerning LVE suggest that both developmental and degenerative processes underlie this abnormality. The association of LVE and third VE with a poor outcome indicates that qualitative MRI evaluation might be of clinical relevance. Copyright (C) 2000 Elsevier Science Ireland Ltd.

KW - Chronicity

KW - CNS developmental abnormalities

KW - Outcome

KW - Structural brain abnormalities

UR - http://www.scopus.com/inward/record.url?scp=0034630430&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0034630430&partnerID=8YFLogxK

U2 - 10.1016/S0925-4927(00)00047-0

DO - 10.1016/S0925-4927(00)00047-0

M3 - Article

VL - 98

SP - 117

EP - 126

JO - Psychiatry Research - Neuroimaging

JF - Psychiatry Research - Neuroimaging

SN - 0925-4927

IS - 2

ER -