Three patients previously classified as ITP are described in whom splenectomy was followed by strong increase in platelet count; in 2 of them there was no effect on haemorrhagic diathesis. The functional and ultrastructural studies of their platelets showed that the first was affected by Glanzmann's thrombasthenia, the second by a hitherto unclassified thrombocytopathy, and the third by storage-pool disease. This study suggests that the thrombocytopenic phases of thrombocytopathies can be mistaken for ITP. Platelet-function studies in thrombocytopenic patients, although difficult to perform, provide the only means of distinguishing the two forms, this being important since the prognostic and therapeutic implications are different.
|Number of pages||9|
|Publication status||Published - 1982|
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