Qualitative platelet defects in three cases previously classified as idiopathic thrombocytopenic purpura and treated with splenectomy

G. Grignani, D. Geroldi, A. Marchi, C. Dell'Orbo, F. Bagliani, G. Gamba

Research output: Contribution to journalArticlepeer-review

Abstract

Three patients previously classified as ITP are described in whom splenectomy was followed by strong increase in platelet count; in 2 of them there was no effect on haemorrhagic diathesis. The functional and ultrastructural studies of their platelets showed that the first was affected by Glanzmann's thrombasthenia, the second by a hitherto unclassified thrombocytopathy, and the third by storage-pool disease. This study suggests that the thrombocytopenic phases of thrombocytopathies can be mistaken for ITP. Platelet-function studies in thrombocytopenic patients, although difficult to perform, provide the only means of distinguishing the two forms, this being important since the prognostic and therapeutic implications are different.

Original languageEnglish
Pages (from-to)246-254
Number of pages9
JournalHaematologica
Volume67
Issue number2
Publication statusPublished - 1982

ASJC Scopus subject areas

  • Hematology

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